Munier-Lehmann H - Search Results

1

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.

Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M. Haouz A, et al. J Biol Chem. 2003 Feb 14;278(7):4963-71. doi: 10.1074/jbc.M209630200. Epub 2002 Nov 25. J Biol Chem. 2003. PMID: 12454011 Free article.

2

Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis.

Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M. Li de la Sierra I, et al. Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):226-8. doi: 10.1107/s0907444999016212. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10666613

3

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes.

Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G. Munier-Lehmann H, et al. Protein Sci. 2001 Jun;10(6):1195-205. doi: 10.1110/ps.45701. Protein Sci. 2001. PMID: 11369858 Free PMC article.

4

X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution.

Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M. Li de la Sierra I, et al. J Mol Biol. 2001 Aug 3;311(1):87-100. doi: 10.1006/jmbi.2001.4843. J Mol Biol. 2001. PMID: 11469859

5

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2695-8. doi: 10.1016/s0960-894x(02)00551-6. Bioorg Med Chem Lett. 2002. PMID: 12217356

6

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.

Manallack DT, Pitt WR, Herdewijn P, Balzarini J, De Clercq E, Sanderson MR, Sohi M, Wien F, Munier-Lehmann H, Haouz A, Delarue M. Manallack DT, et al. J Enzyme Inhib Med Chem. 2002 Jun;17(3):167-74. doi: 10.1080/14756360290032949. J Enzyme Inhib Med Chem. 2002. PMID: 12443042 Free article.

7

Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway.

Fioravanti E, Haouz A, Ursby T, Munier-Lehmann H, Delarue M, Bourgeois D. Fioravanti E, et al. J Mol Biol. 2003 Apr 11;327(5):1077-92. doi: 10.1016/s0022-2836(03)00202-x. J Mol Biol. 2003. PMID: 12662932

8

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.

Pochet S, Dugué L, Labesse G, Delepierre M, Munier-Lehmann H. Pochet S, et al. Chembiochem. 2003 Aug 4;4(8):742-7. doi: 10.1002/cbic.200300608. Chembiochem. 2003. PMID: 12898625

9

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Vanheusden V, Munier-Lehmann H, Froeyen M, Dugué L, Heyerick A, De Keukeleire D, Pochet S, Busson R, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. J Med Chem. 2003 Aug 28;46(18):3811-21. doi: 10.1021/jm021108n. J Med Chem. 2003. PMID: 12930144 Free article.

10

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3045-8. doi: 10.1016/s0960-894x(03)00643-7. Bioorg Med Chem Lett. 2003. PMID: 12941330

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