Van der Schyf CJ - Search Results

1

Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative.

Ooms F, Frédérick R, Durant F, Petzer JP, Castagnoli N, Van der Schyf CJ, Wouters J. Ooms F, et al. Among authors: van der schyf cj. Bioorg Med Chem Lett. 2003 Jan 6;13(1):69-73. doi: 10.1016/s0960-894x(02)00838-7. Bioorg Med Chem Lett. 2003. PMID: 12467619

2

Inhibition of monoamine oxidase B by selective adenosine A2A receptor antagonists.

Petzer JP, Steyn S, Castagnoli KP, Chen JF, Schwarzschild MA, Van der Schyf CJ, Castagnoli N. Petzer JP, et al. Among authors: van der schyf cj. Bioorg Med Chem. 2003 Apr 3;11(7):1299-310. doi: 10.1016/s0968-0896(02)00648-x. Bioorg Med Chem. 2003. PMID: 12628657

3

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core.

Frédérick R, Dumont W, Ooms F, Aschenbach L, Van der Schyf CJ, Castagnoli N, Wouters J, Krief A. Frédérick R, et al. Among authors: van der schyf cj. J Med Chem. 2006 Jun 15;49(12):3743-7. doi: 10.1021/jm051091j. J Med Chem. 2006. PMID: 16759116

4

8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism.

Chen JF, Steyn S, Staal R, Petzer JP, Xu K, Van Der Schyf CJ, Castagnoli K, Sonsalla PK, Castagnoli N Jr, Schwarzschild MA. Chen JF, et al. Among authors: van der schyf cj. J Biol Chem. 2002 Sep 27;277(39):36040-4. doi: 10.1074/jbc.M206830200. Epub 2002 Jul 18. J Biol Chem. 2002. PMID: 12130655 Free article.

5

Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonists.

Castagnoli N Jr, Petzer JP, Steyn S, Castagnoli K, Chen JF, Schwarzschild MA, Van der Schyf CJ. Castagnoli N Jr, et al. Among authors: van der schyf cj. Neurology. 2003 Dec 9;61(11 Suppl 6):S62-8. doi: 10.1212/01.wnl.0000095215.97585.59. Neurology. 2003. PMID: 14663013

6

(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B.

Frédérick R, Ooms F, Castagnoli N Jr, Petzer JP, Feng JF, Schwarzschild MA, Van der Schyf CJ, Wouters J. Frédérick R, et al. Among authors: van der schyf cj. Acta Crystallogr C. 2005 Sep;61(Pt 9):o531-2. doi: 10.1107/S0108270105023140. Epub 2005 Aug 10. Acta Crystallogr C. 2005. PMID: 16143772

7

Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease.

Petzer JP, Castagnoli N Jr, Schwarzschild MA, Chen JF, Van der Schyf CJ. Petzer JP, et al. Among authors: van der schyf cj. Neurotherapeutics. 2009 Jan;6(1):141-51. doi: 10.1016/j.nurt.2008.10.035. Neurotherapeutics. 2009. PMID: 19110205 Free PMC article. Review.

8

Neuroprotection in the MPTP Parkinsonian C57BL/6 mouse model by a compound isolated from tobacco.

Castagnoli KP, Steyn SJ, Petzer JP, Van der Schyf CJ, Castagnoli N Jr. Castagnoli KP, et al. Among authors: van der schyf cj. Chem Res Toxicol. 2001 May;14(5):523-7. doi: 10.1021/tx000224v. Chem Res Toxicol. 2001. PMID: 11368550

9

Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.

Geldenhuys WJ, Darvesh AS, Funk MO, Van der Schyf CJ, Carroll RT. Geldenhuys WJ, et al. Among authors: van der schyf cj. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5295-8. doi: 10.1016/j.bmcl.2010.06.128. Epub 2010 Jul 1. Bioorg Med Chem Lett. 2010. PMID: 20650633

10

Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.

Inoue H, Castagnoli K, Van Der Schyf C, Mabic S, Igarashi K, Castagnoli N Jr. Inoue H, et al. J Pharmacol Exp Ther. 1999 Nov;291(2):856-64. J Pharmacol Exp Ther. 1999. PMID: 10525109

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