Hamilton AD - Search Results

1

Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.

Mazzocca A, Giusti S, Hamilton AD, Sebti SM, Pantaleo P, Carloni V. Mazzocca A, et al. Among authors: hamilton ad. Mol Pharmacol. 2003 Jan;63(1):159-66. doi: 10.1124/mol.63.1.159. Mol Pharmacol. 2003. PMID: 12488548

2

Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells.

Carloni V, Pinzani M, Giusti S, Romanelli RG, Parola M, Bellomo G, Failli P, Hamilton AD, Sebti SM, Laffi G, Gentilini P. Carloni V, et al. Among authors: hamilton ad. Hepatology. 2000 Jan;31(1):131-40. doi: 10.1002/hep.510310121. Hepatology. 2000. PMID: 10613738

3

Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling.

Guida WC, Hamilton AD, Crotty JW, Sebti SM. Guida WC, et al. Among authors: hamilton ad. J Comput Aided Mol Des. 2005 Dec;19(12):871-85. doi: 10.1007/s10822-005-9030-2. Epub 2006 May 12. J Comput Aided Mol Des. 2005. PMID: 16607571

4

Farnesyltransferase inhibitors as anticancer agents: current status.

Zhu K, Hamilton AD, Sebti SM. Zhu K, et al. Among authors: hamilton ad. Curr Opin Investig Drugs. 2003 Dec;4(12):1428-35. Curr Opin Investig Drugs. 2003. PMID: 14763128 Review.

5

Farnesyltransferase as a target for anticancer drug design.

Qian Y, Sebti SM, Hamilton AD. Qian Y, et al. Among authors: hamilton ad. Biopolymers. 1997;43(1):25-41. doi: 10.1002/(SICI)1097-0282(1997)43:1<25::AID-BIP4>3.0.CO;2-2. Biopolymers. 1997. PMID: 9174410 Review.

6

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Pharmacol Ther. 1997;74(1):103-14. doi: 10.1016/s0163-7258(97)00014-4. Pharmacol Ther. 1997. PMID: 9336018 Review.

7

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis.

Jiang K, Coppola D, Crespo NC, Nicosia SV, Hamilton AD, Sebti SM, Cheng JQ. Jiang K, et al. Among authors: hamilton ad. Mol Cell Biol. 2000 Jan;20(1):139-48. doi: 10.1128/MCB.20.1.139-148.2000. Mol Cell Biol. 2000. PMID: 10594016 Free PMC article.

8

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Expert Opin Investig Drugs. 2000 Dec;9(12):2767-82. doi: 10.1517/13543784.9.12.2767. Expert Opin Investig Drugs. 2000. PMID: 11093352 Review.

9

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

Crespo NC, Ohkanda J, Yen TJ, Hamilton AD, Sebti SM. Crespo NC, et al. Among authors: hamilton ad. J Biol Chem. 2001 May 11;276(19):16161-7. doi: 10.1074/jbc.M006213200. Epub 2001 Jan 11. J Biol Chem. 2001. PMID: 11154688 Free article.

10

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Oncogene. 2000 Dec 27;19(56):6584-93. doi: 10.1038/sj.onc.1204146. Oncogene. 2000. PMID: 11426643 Review.

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