Gavilanes JG - Search Results

1

Leucine 145 of the ribotoxin alpha-sarcin plays a key role for determining the specificity of the ribosome-inactivating activity of the protein.

Masip M, García-Ortega L, Olmo N, García-Mayoral MF, Pérez-Cañadillas JM, Bruix M, Oñaderra M, Martínez del Pozo A, Gavilanes JG. Masip M, et al. Among authors: gavilanes jg. Protein Sci. 2003 Jan;12(1):161-9. doi: 10.1110/ps.0225903. Protein Sci. 2003. PMID: 12493839 Free PMC article.

2

Deletion of the NH2-terminal beta-hairpin of the ribotoxin alpha-sarcin produces a nontoxic but active ribonuclease.

Garcia-Ortega L, Masip M, Mancheño JM, Oñaderra M, Lizarbe MA, García-Mayoral MF, Bruix M, Martínez del Pozo A, Gavilanes JG. Garcia-Ortega L, et al. Among authors: gavilanes jg. J Biol Chem. 2002 May 24;277(21):18632-9. doi: 10.1074/jbc.M200922200. Epub 2002 Mar 15. J Biol Chem. 2002. PMID: 11897788 Free article.

3

Tautomeric state of alpha-sarcin histidines. Ndelta tautomers are a common feature in the active site of extracellular microbial ribonucleases.

Pérez-Cañadilllas JM, García-Mayoral MF, Laurents DV, Martínez del Pozo A, Gavilanes JG, Rico M, Bruix M. Pérez-Cañadilllas JM, et al. Among authors: gavilanes jg. FEBS Lett. 2003 Jan 16;534(1-3):197-201. doi: 10.1016/s0014-5793(02)03844-9. FEBS Lett. 2003. PMID: 12527386 Free article.

4

Dissecting structural and electrostatic interactions of charged groups in alpha-sarcin. An NMR study of some mutants involving the catalytic residues.

García-Mayoral MF, Pérez-Cañadillas JM, Santoro J, Ibarra-Molero B, Sanchez-Ruiz JM, Lacadena J, Martínez del Pozo A, Gavilanes JG, Rico M, Bruix M. García-Mayoral MF, et al. Among authors: gavilanes jg. Biochemistry. 2003 Nov 18;42(45):13122-33. doi: 10.1021/bi0349773. Biochemistry. 2003. PMID: 14609322

5

NMR structure of the noncytotoxic alpha-sarcin mutant Delta(7-22): the importance of the native conformation of peripheral loops for activity.

García-Mayoral MF, García-Ortega L, Lillo MP, Santoro J, Martínez del Pozo A, Gavilanes JG, Rico M, Bruix M. García-Mayoral MF, et al. Among authors: gavilanes jg. Protein Sci. 2004 Apr;13(4):1000-11. doi: 10.1110/ps.03532204. Protein Sci. 2004. PMID: 15044731 Free PMC article.

6

Conserved asparagine residue 54 of alpha-sarcin plays a role in protein stability and enzyme activity.

Siemer A, Masip M, Carreras N, García-Ortega L, Oñaderra M, Bruix M, Del Pozo AM, Gavilanes JG. Siemer A, et al. Among authors: gavilanes jg. Biol Chem. 2004 Dec;385(12):1165-70. doi: 10.1515/BC.2004.150. Biol Chem. 2004. PMID: 15653429

7

Modeling the highly specific ribotoxin recognition of ribosomes.

García-Mayoral F, García-Ortega L, Alvarez-García E, Bruix M, Gavilanes JG, del Pozo AM. García-Mayoral F, et al. Among authors: gavilanes jg. FEBS Lett. 2005 Dec 19;579(30):6859-64. doi: 10.1016/j.febslet.2005.11.027. Epub 2005 Dec 1. FEBS Lett. 2005. PMID: 16337202 Free article.

8

Tyr-48, a conserved residue in ribotoxins, is involved in the RNA-degrading activity of alpha-sarcin.

Alvarez-García E, García-Ortega L, Verdún Y, Bruix M, Martínez del Pozo A, Gavilanes JG. Alvarez-García E, et al. Among authors: gavilanes jg. Biol Chem. 2006 May;387(5):535-41. doi: 10.1515/BC.2006.069. Biol Chem. 2006. PMID: 16740124

9

pH-Dependent conformational stability of the ribotoxin alpha-sarcin and four active site charge substitution variants.

García-Mayoral MF, del Pozo AM, Campos-Olivas R, Gavilanes JG, Santoro J, Rico M, Laurents DV, Bruix M. García-Mayoral MF, et al. Among authors: gavilanes jg. Biochemistry. 2006 Nov 21;45(46):13705-18. doi: 10.1021/bi061273v. Biochemistry. 2006. PMID: 17105190

10

The insecticidal protein hirsutellin A from the mite fungal pathogen Hirsutella thompsonii is a ribotoxin.

Herrero-Galán E, Lacadena J, Martínez del Pozo A, Boucias DG, Olmo N, Oñaderra M, Gavilanes JG. Herrero-Galán E, et al. Among authors: gavilanes jg. Proteins. 2008 Jul;72(1):217-28. doi: 10.1002/prot.21910. Proteins. 2008. PMID: 18214983

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