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Page 1
The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ. Brown AJ, et al. Among authors: muir ai. J Biol Chem. 2003 Mar 28;278(13):11312-9. doi: 10.1074/jbc.M211609200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496283 Free article.
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI. Briscoe CP, et al. Among authors: muir ai. J Biol Chem. 2003 Mar 28;278(13):11303-11. doi: 10.1074/jbc.M211495200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496284 Free article.
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.
Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC. Muir AI, et al. J Biol Chem. 2001 Aug 3;276(31):28969-75. doi: 10.1074/jbc.M102743200. Epub 2001 May 31. J Biol Chem. 2001. PMID: 11387329 Free article.
Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.
Szekeres PG, Muir AI, Spinage LD, Miller JE, Butler SI, Smith A, Rennie GI, Murdock PR, Fitzgerald LR, Wu Hl, McMillan LJ, Guerrera S, Vawter L, Elshourbagy NA, Mooney JL, Bergsma DJ, Wilson S, Chambers JK. Szekeres PG, et al. Among authors: muir ai. J Biol Chem. 2000 Jul 7;275(27):20247-50. doi: 10.1074/jbc.C000244200. J Biol Chem. 2000. PMID: 10811630 Free article.
Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.
Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI. Hill J, et al. Among authors: muir ai. J Biol Chem. 2001 Jun 8;276(23):20125-9. doi: 10.1074/jbc.M102068200. Epub 2001 Mar 27. J Biol Chem. 2001. PMID: 11274220 Free article.
Orphan G-protein-coupled receptors: the next generation of drug targets?
Wilson S, Bergsma DJ, Chambers JK, Muir AI, Fantom KG, Ellis C, Murdock PR, Herrity NC, Stadel JM. Wilson S, et al. Among authors: muir ai. Br J Pharmacol. 1998 Dec;125(7):1387-92. doi: 10.1038/sj.bjp.0702238. Br J Pharmacol. 1998. PMID: 9884064 Free PMC article. Review.
Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.
Heightman TD, Scott JS, Longley M, Bordas V, Dean DK, Elliott R, Hutley G, Witherington J, Abberley L, Passingham B, Berlanga M, de Los Frailes M, Wise A, Powney B, Muir A, McKay F, Butler S, Winborn K, Gardner C, Darton J, Campbell C, Sanger G. Heightman TD, et al. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6584-7. doi: 10.1016/j.bmcl.2007.09.067. Epub 2007 Sep 25. Bioorg Med Chem Lett. 2007. PMID: 17942309
Identification of small molecule agonists of the motilin receptor.
Heightman TD, Conway E, Corbett DF, Macdonald GJ, Stemp G, Westaway SM, Celestini P, Gagliardi S, Riccaboni M, Ronzoni S, Vaidya K, Butler S, McKay F, Muir A, Powney B, Winborn K, Wise A, Jarvie EM, Sanger GJ. Heightman TD, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6423-8. doi: 10.1016/j.bmcl.2008.10.071. Epub 2008 Oct 19. Bioorg Med Chem Lett. 2008. PMID: 18980843
28 results