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The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4.

Mansouri M, Bartee E, Gouveia K, Hovey Nerenberg BT, Barrett J, Thomas L, Thomas G, McFadden G, Früh K. Mansouri M, et al. Among authors: hovey nerenberg bt. J Virol. 2003 Jan;77(2):1427-40. doi: 10.1128/jvi.77.2.1427-1440.2003. J Virol. 2003. PMID: 12502858 Free PMC article.

Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.

Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Früh K. Bartee E, et al. Among authors: hovey nerenberg bt. J Virol. 2004 Feb;78(3):1109-20. doi: 10.1128/jvi.78.3.1109-1120.2004. J Virol. 2004. PMID: 14722266 Free PMC article.

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