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The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, Wang HS, Schultz Jel J, Molkentin JD, Liggett SB, Dorn GW 2nd, Kranias EG. Zhao W, et al. Circulation. 2006 Feb 21;113(7):995-1004. doi: 10.1161/CIRCULATIONAHA.105.583351. Epub 2006 Feb 13. Circulation. 2006. PMID: 16476846
Structure and expression of the mouse cardiac calsequestrin gene.
Frank KF, Mesnard-Rouiller L, Chu G, Young KB, Zhao W, Haghighi K, Sato Y, Kranias EG. Frank KF, et al. Among authors: zhao w. Basic Res Cardiol. 2001 Nov;96(6):636-44. doi: 10.1007/s003950170016. Basic Res Cardiol. 2001. PMID: 11770083
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD. Braz JC, et al. Among authors: zhao w. Nat Med. 2004 Mar;10(3):248-54. doi: 10.1038/nm1000. Epub 2004 Feb 15. Nat Med. 2004. PMID: 14966518 Free article.
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.
Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, McGraw DW, Heist EK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, Kranias EG. Pathak A, et al. Among authors: zhao w. Circ Res. 2005 Apr 15;96(7):756-66. doi: 10.1161/01.RES.0000161256.85833.fa. Epub 2005 Mar 3. Circ Res. 2005. PMID: 15746443
Junctin is a prominent regulator of contractility in cardiomyocytes.
Fan GC, Yuan Q, Zhao W, Chu G, Kranias EG. Fan GC, et al. Among authors: zhao w. Biochem Biophys Res Commun. 2007 Jan 19;352(3):617-22. doi: 10.1016/j.bbrc.2006.11.093. Epub 2006 Nov 27. Biochem Biophys Res Commun. 2007. PMID: 17150191 Free PMC article.
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