Liljefors T - Search Results

1

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.

Hogner A, Greenwood JR, Liljefors T, Lunn ML, Egebjerg J, Larsen IK, Gouaux E, Kastrup JS. Hogner A, et al. Among authors: liljefors t. J Med Chem. 2003 Jan 16;46(2):214-21. doi: 10.1021/jm020989v. J Med Chem. 2003. PMID: 12519060

2

Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).

Bjerrum EJ, Kristensen AS, Pickering DS, Greenwood JR, Nielsen B, Liljefors T, Schousboe A, Bräuner-Osborne H, Madsen U. Bjerrum EJ, et al. Among authors: liljefors t. J Med Chem. 2003 May 22;46(11):2246-9. doi: 10.1021/jm020588f. J Med Chem. 2003. PMID: 12747796

3

The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.

Kasper C, Pickering DS, Mirza O, Olsen L, Kristensen AS, Greenwood JR, Liljefors T, Schousboe A, Wätjen F, Gajhede M, Sigurskjold BW, Kastrup JS. Kasper C, et al. Among authors: liljefors t. J Mol Biol. 2006 Apr 7;357(4):1184-201. doi: 10.1016/j.jmb.2006.01.024. Epub 2006 Jan 31. J Mol Biol. 2006. PMID: 16483599

4

Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.

Hald H, Naur P, Pickering DS, Sprogøe D, Madsen U, Timmermann DB, Ahring PK, Liljefors T, Schousboe A, Egebjerg J, Gajhede M, Kastrup JS. Hald H, et al. Among authors: liljefors t. J Biol Chem. 2007 Aug 31;282(35):25726-36. doi: 10.1074/jbc.M700137200. Epub 2007 Jun 20. J Biol Chem. 2007. PMID: 17581823 Free article.

5

Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.

Beich-Frandsen M, Pickering DS, Mirza O, Johansen TN, Greenwood J, Vestergaard B, Schousboe A, Gajhede M, Liljefors T, Kastrup JS. Beich-Frandsen M, et al. Among authors: liljefors t. J Med Chem. 2008 Mar 13;51(5):1459-63. doi: 10.1021/jm701126w. Epub 2008 Feb 13. J Med Chem. 2008. PMID: 18269227

6

Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.

Hogner A, Kastrup JS, Jin R, Liljefors T, Mayer ML, Egebjerg J, Larsen IK, Gouaux E. Hogner A, et al. Among authors: liljefors t. J Mol Biol. 2002 Sep 6;322(1):93-109. doi: 10.1016/s0022-2836(02)00650-2. J Mol Biol. 2002. PMID: 12215417

7

GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists.

Kasper C, Lunn ML, Liljefors T, Gouaux E, Egebjerg J, Kastrup JS. Kasper C, et al. Among authors: liljefors t. FEBS Lett. 2002 Nov 6;531(2):173-8. doi: 10.1016/s0014-5793(02)03496-8. FEBS Lett. 2002. PMID: 12417307 Free article.

8

Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.

Bunch L, Liljefors T, Greenwood JR, Frydenvang K, Bräuner-Osborne H, Krogsgaard-Larsen P, Madsen U. Bunch L, et al. Among authors: liljefors t. J Org Chem. 2003 Feb 21;68(4):1489-95. doi: 10.1021/jo026509p. J Org Chem. 2003. PMID: 12585893

9

A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

Vogensen SB, Greenwood JR, Varming AR, Brehm L, Pickering DS, Nielsen B, Liljefors T, Clausen RP, Johansen TN, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: liljefors t. Org Biomol Chem. 2004 Jan 21;2(2):206-13. doi: 10.1039/b310450h. Epub 2003 Nov 24. Org Biomol Chem. 2004. PMID: 14737644

10

Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites.

Kaae BH, Harpsøe K, Kastrup JS, Sanz AC, Pickering DS, Metzler B, Clausen RP, Gajhede M, Sauerberg P, Liljefors T, Madsen U. Kaae BH, et al. Among authors: liljefors t. Chem Biol. 2007 Nov;14(11):1294-303. doi: 10.1016/j.chembiol.2007.10.012. Chem Biol. 2007. PMID: 18022568

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