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Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling.
Dormond O, Bezzi M, Mariotti A, Ruegg C. Dormond O, et al. J Biol Chem. 2002 Nov 29;277(48):45838-46. doi: 10.1074/jbc.M209213200. Epub 2002 Sep 16. J Biol Chem. 2002. PMID: 12237321 Free article.
We have recently reported that the inhibition of endothelial cell COX-2 by non-steroidal anti-inflammatory drugs suppresses alpha(V)beta(3)- (but not alpha(5)beta(1)-) dependent Rac activation, endothelial cell spreading, migration, and angiogenesis (Dormond, O., Fo …
We have recently reported that the inhibition of endothelial cell COX-2 by non-steroidal anti-inflammatory drugs suppresses alpha(V)beta(3)- …
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