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Page 1
The design of potent hydrazones and disulfides as cathepsin S inhibitors.
Cywin CL, Firestone RA, McNeil DW, Grygon CA, Crane KM, White DM, Kinkade PR, Hopkins JL, Davidson W, Labadia ME, Wildeson J, Morelock MM, Peterson JD, Raymond EL, Brown ML, Spero DM. Cywin CL, et al. Among authors: brown ml. Bioorg Med Chem. 2003 Mar 6;11(5):733-40. doi: 10.1016/s0968-0896(02)00468-6. Bioorg Med Chem. 2003. PMID: 12538003
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.
Ward YD, Thomson DS, Frye LL, Cywin CL, Morwick T, Emmanuel MJ, Zindell R, McNeil D, Bekkali Y, Girardot M, Hrapchak M, DeTuri M, Crane K, White D, Pav S, Wang Y, Hao MH, Grygon CA, Labadia ME, Freeman DM, Davidson W, Hopkins JL, Brown ML, Spero DM. Ward YD, et al. Among authors: brown ml. J Med Chem. 2002 Dec 5;45(25):5471-82. doi: 10.1021/jm020209i. J Med Chem. 2002. PMID: 12459015
Discovery of potent and selective PKC-theta inhibitors.
Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG, Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H, Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR Jr, Brown ML. Cywin CL, et al. Among authors: brown ml. Bioorg Med Chem Lett. 2007 Jan 1;17(1):225-30. doi: 10.1016/j.bmcl.2006.09.056. Epub 2006 Oct 19. Bioorg Med Chem Lett. 2007. PMID: 17055721
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors.
Bekkali Y, Thomson DS, Betageri R, Emmanuel MJ, Hao MH, Hickey E, Liu W, Patel U, Ward YD, Young ER, Nelson R, Kukulka A, Brown ML, Crane K, White D, Freeman DM, Labadia ME, Wildeson J, Spero DM. Bekkali Y, et al. Among authors: brown ml. Bioorg Med Chem Lett. 2007 May 1;17(9):2465-9. doi: 10.1016/j.bmcl.2007.02.046. Epub 2007 Feb 23. Bioorg Med Chem Lett. 2007. PMID: 17379516
Discovery and optimization of pyrazole amides as antagonists of CCR1.
Harcken C, Sarko C, Mao C, Lord J, Raudenbush B, Razavi H, Liu P, Swinamer A, Disalvo D, Lee T, Lin S, Kukulka A, Grbic H, Patel M, Patel M, Fletcher K, Joseph D, White D, Amodeo L, Berg K, Brown M, Thomson DS. Harcken C, et al. Bioorg Med Chem Lett. 2019 Feb 1;29(3):435-440. doi: 10.1016/j.bmcl.2018.11.015. Epub 2018 Nov 9. Bioorg Med Chem Lett. 2019. PMID: 30455146
881 results