Kliewer SA - Search Results

1

Functional and structural comparison of PXR and CAR.

Moore JT, Moore LB, Maglich JM, Kliewer SA. Moore JT, et al. Among authors: kliewer sa. Biochim Biophys Acta. 2003 Feb 17;1619(3):235-8. doi: 10.1016/s0304-4165(02)00481-6. Biochim Biophys Acta. 2003. PMID: 12573482 Review.

2

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.

Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, Moore JT. Moore LB, et al. Among authors: kliewer sa. Mol Endocrinol. 2002 May;16(5):977-86. doi: 10.1210/mend.16.5.0828. Mol Endocrinol. 2002. PMID: 11981033

3

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA. Maglich JM, et al. Among authors: kliewer sa. Mol Pharmacol. 2002 Sep;62(3):638-46. doi: 10.1124/mol.62.3.638. Mol Pharmacol. 2002. PMID: 12181440

4

Nuclear receptor regulation of genes involved in bile acid metabolism.

Moore JT, Goodwin B, Willson TM, Kliewer SA. Moore JT, et al. Among authors: kliewer sa. Crit Rev Eukaryot Gene Expr. 2002;12(2):119-35. doi: 10.1615/critreveukaryotgeneexpr.v12.i2.30. Crit Rev Eukaryot Gene Expr. 2002. PMID: 12434926 Review.

5

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.

Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT. Maglich JM, et al. Among authors: kliewer sa. J Biol Chem. 2003 May 9;278(19):17277-83. doi: 10.1074/jbc.M300138200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12611900 Free article.

6

Use of the nuclear receptor PXR to predict drug interactions.

Moore JT, Kliewer SA. Moore JT, et al. Among authors: kliewer sa. Toxicology. 2000 Nov 16;153(1-3):1-10. doi: 10.1016/s0300-483x(00)00300-0. Toxicology. 2000. PMID: 11090943 Review.

7

Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism.

Willson TM, Jones SA, Moore JT, Kliewer SA. Willson TM, et al. Among authors: kliewer sa. Med Res Rev. 2001 Nov;21(6):513-22. doi: 10.1002/med.1023. Med Res Rev. 2001. PMID: 11607932 Review.

8

CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.

Tippin TK, Hamilton G, Moore L, Beaudet EJ, Jolley S, Brodie TA, Andrews RC, Becherer JD, McDougald DL, Gaul MD, Hoivik DJ, Mellon-Kusibab K, Lehmann J, Kliewer S, Novick S, Laethem R, Zhao Z, LeCluyse EL. Tippin TK, et al. Drug Metab Dispos. 2003 Jul;31(7):870-7. doi: 10.1124/dmd.31.7.870. Drug Metab Dispos. 2003. PMID: 12814963

9

Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates.

Jones SA, Moore LB, Wisely GB, Kliewer SA. Jones SA, et al. Among authors: kliewer sa. Methods Enzymol. 2002;357:161-70. doi: 10.1016/s0076-6879(02)57675-8. Methods Enzymol. 2002. PMID: 12424907 No abstract available.

10

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.

Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR. Watkins RE, et al. Among authors: kliewer sa. Biochemistry. 2003 Feb 18;42(6):1430-8. doi: 10.1021/bi0268753. Biochemistry. 2003. PMID: 12578355

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