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An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain.
Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A. Amiry-Moghaddam M, et al. Among authors: froehner sc. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2106-11. doi: 10.1073/pnas.0437946100. Epub 2003 Feb 10. Proc Natl Acad Sci U S A. 2003. PMID: 12578959 Free PMC article.
Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice.
Amiry-Moghaddam M, Williamson A, Palomba M, Eid T, de Lanerolle NC, Nagelhus EA, Adams ME, Froehner SC, Agre P, Ottersen OP. Amiry-Moghaddam M, et al. Among authors: froehner sc. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13615-20. doi: 10.1073/pnas.2336064100. Epub 2003 Nov 3. Proc Natl Acad Sci U S A. 2003. PMID: 14597704 Free PMC article.
Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia.
Amiry-Moghaddam M, Xue R, Haug FM, Neely JD, Bhardwaj A, Agre P, Adams ME, Froehner SC, Mori S, Ottersen OP. Amiry-Moghaddam M, et al. Among authors: froehner sc. FASEB J. 2004 Mar;18(3):542-4. doi: 10.1096/fj.03-0869fje. Epub 2004 Jan 20. FASEB J. 2004. PMID: 14734638
153 results