Tyndall JD - Search Results

1

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity.

Hansford KA, Reid RC, Clark CI, Tyndall JD, Whitehouse MW, Guthrie T, McGeary RP, Schafer K, Martin JL, Fairlie DP. Hansford KA, et al. Among authors: tyndall jd. Chembiochem. 2003 Mar 3;4(2-3):181-5. doi: 10.1002/cbic.200390029. Chembiochem. 2003. PMID: 12616631

2

Conformational homogeneity in molecular recognition by proteolytic enzymes.

Tyndall JD, Fairlie DP. Tyndall JD, et al. J Mol Recognit. 1999 Nov-Dec;12(6):363-70. doi: 10.1002/(SICI)1099-1352(199911/12)12:6<363::AID-JMR478>3.0.CO;2-M. J Mol Recognit. 1999. PMID: 10611646 Review.

3

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing.

Fairlie DP, Tyndall JD, Reid RC, Wong AK, Abbenante G, Scanlon MJ, March DR, Bergman DA, Chai CL, Burkett BA. Fairlie DP, et al. Among authors: tyndall jd. J Med Chem. 2000 Apr 6;43(7):1271-81. doi: 10.1021/jm990315t. J Med Chem. 2000. PMID: 10753465

4

Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.

Tyndall JD, Reid RC, Tyssen DP, Jardine DK, Todd B, Passmore M, March DR, Pattenden LK, Bergman DA, Alewood D, Hu SH, Alewood PF, Birch CJ, Martin JL, Fairlie DP. Tyndall JD, et al. J Med Chem. 2000 Sep 21;43(19):3495-504. doi: 10.1021/jm000013n. J Med Chem. 2000. PMID: 11000004

5

Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases.

Tyndall JD, Fairlie DP. Tyndall JD, et al. Curr Med Chem. 2001 Jul;8(8):893-907. doi: 10.2174/0929867013372715. Curr Med Chem. 2001. PMID: 11375757 Review.

6

Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.

Glenn MP, Pattenden LK, Reid RC, Tyssen DP, Tyndall JD, Birch CJ, Fairlie DP. Glenn MP, et al. Among authors: tyndall jd. J Med Chem. 2002 Jan 17;45(2):371-81. doi: 10.1021/jm010414i. J Med Chem. 2002. PMID: 11784141

7

Conformationally homogeneous cyclic tetrapeptides: useful new three-dimensional scaffolds.

Glenn MP, Kelso MJ, Tyndall JD, Fairlie DP. Glenn MP, et al. Among authors: tyndall jd. J Am Chem Soc. 2003 Jan 22;125(3):640-1. doi: 10.1021/ja029205t. J Am Chem Soc. 2003. PMID: 12526657

8

Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints.

Lucke AJ, Tyndall JD, Singh Y, Fairlie DP. Lucke AJ, et al. Among authors: tyndall jd. J Mol Graph Model. 2003 Mar;21(5):341-55. doi: 10.1016/s1093-3263(02)00181-x. J Mol Graph Model. 2003. PMID: 12543133

9

Countering cooperative effects in protease inhibitors using constrained beta-strand-mimicking templates in focused combinatorial libraries.

Reid RC, Pattenden LK, Tyndall JD, Martin JL, Walsh T, Fairlie DP. Reid RC, et al. Among authors: tyndall jd. J Med Chem. 2004 Mar 25;47(7):1641-51. doi: 10.1021/jm030337m. J Med Chem. 2004. PMID: 15027855

10

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

March DR, Proctor LM, Stoermer MJ, Sbaglia R, Abbenante G, Reid RC, Woodruff TM, Wadi K, Paczkowski N, Tyndall JD, Taylor SM, Fairlie DP. March DR, et al. Among authors: tyndall jd. Mol Pharmacol. 2004 Apr;65(4):868-79. doi: 10.1124/mol.65.4.868. Mol Pharmacol. 2004. PMID: 15044616

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