Wroblewski VJ - Search Results

1

Pharmacokinetics, metabolic stability, and subcutaneous bioavailability of a genetically engineered analog of DcR3, FLINT [DcR3(R218Q)], in cynomolgus monkeys and mice.

Wroblewski VJ, McCloud C, Davis K, Manetta J, Micanovic R, Witcher DR. Wroblewski VJ, et al. Drug Metab Dispos. 2003 Apr;31(4):502-7. doi: 10.1124/dmd.31.4.502. Drug Metab Dispos. 2003. PMID: 12642478

2

Decoy receptor 3 (DcR3) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT.

Wroblewski VJ, Witcher DR, Becker GW, Davis KA, Dou S, Micanovic R, Newton CM, Noblitt TW, Richardson JM, Song HY, Hale JE. Wroblewski VJ, et al. Biochem Pharmacol. 2003 Feb 15;65(4):657-67. doi: 10.1016/s0006-2952(02)01612-x. Biochem Pharmacol. 2003. PMID: 12566095

3

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.

Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Jiang W, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. Drug Metab Dispos. 2007 Jan;35(1):86-94. doi: 10.1124/dmd.106.011734. Epub 2006 Oct 18. Drug Metab Dispos. 2007. PMID: 17050651

4

Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor.

Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. J Biol Chem. 2007 Jan 19;282(3):1709-17. doi: 10.1074/jbc.M607161200. Epub 2006 Nov 29. J Biol Chem. 2007. PMID: 17135257 Free article.

5

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.

Datta-Mannan A, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. MAbs. 2012 Mar-Apr;4(2):267-73. doi: 10.4161/mabs.4.2.19364. Epub 2012 Mar 1. MAbs. 2012. PMID: 22377715 Free PMC article.

6

FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.

Datta-Mannan A, Chow CK, Dickinson C, Driver D, Lu J, Witcher DR, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. Drug Metab Dispos. 2012 Aug;40(8):1545-55. doi: 10.1124/dmd.112.045864. Epub 2012 May 14. Drug Metab Dispos. 2012. PMID: 22584253

7

Validation of a de-immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human.

Kovalova N, Boyles J, Wen Y, Witcher DR, Brown-Augsburger PL, Wroblewski VJ, Chlewicki LK. Kovalova N, et al. Among authors: wroblewski vj. Biopharm Drug Dispos. 2020 Mar;41(3):111-125. doi: 10.1002/bdd.2222. Epub 2020 Mar 10. Biopharm Drug Dispos. 2020. PMID: 32080869

8

Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry.

Murphy AT, Witcher DR, Luan P, Wroblewski VJ. Murphy AT, et al. Among authors: wroblewski vj. Blood. 2007 Aug 1;110(3):1048-54. doi: 10.1182/blood-2006-11-057471. Epub 2007 Apr 13. Blood. 2007. PMID: 17435114 Free article.

9

A dual-monoclonal sandwich ELISA specific for hepcidin-25.

Butterfield AM, Luan P, Witcher DR, Manetta J, Murphy AT, Wroblewski VJ, Konrad RJ. Butterfield AM, et al. Among authors: wroblewski vj. Clin Chem. 2010 Nov;56(11):1725-32. doi: 10.1373/clinchem.2010.151522. Epub 2010 Sep 16. Clin Chem. 2010. PMID: 20847326

10

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.

Datta-Mannan A, Thangaraju A, Leung D, Tang Y, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: wroblewski vj. MAbs. 2015;7(3):483-93. doi: 10.1080/19420862.2015.1016696. MAbs. 2015. PMID: 25695748 Free PMC article.

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