Heine P - Search Results

1

Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta).

Naaz A, Zakroczymski M, Heine P, Taylor J, Saunders P, Lubahn D, Cooke PS. Naaz A, et al. Among authors: heine p. Horm Metab Res. 2002 Nov-Dec;34(11-12):758-63. doi: 10.1055/s-2002-38259. Horm Metab Res. 2002. PMID: 12660895

2

Increased adipose tissue in male and female estrogen receptor-alpha knockout mice.

Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS. Heine PA, et al. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12729-34. doi: 10.1073/pnas.97.23.12729. Proc Natl Acad Sci U S A. 2000. PMID: 11070086 Free PMC article.

3

The role of estrogen and estrogen receptor-alpha in male adipose tissue.

Cooke PS, Heine PA, Taylor JA, Lubahn DB. Cooke PS, et al. Among authors: heine pa. Mol Cell Endocrinol. 2001 Jun 10;178(1-2):147-54. doi: 10.1016/s0303-7207(01)00414-2. Mol Cell Endocrinol. 2001. PMID: 11403904 Review.

4

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli.

Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schütz M, Plückthun A. Egloff P, et al. Among authors: heine p. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E655-62. doi: 10.1073/pnas.1317903111. Epub 2014 Jan 22. Proc Natl Acad Sci U S A. 2014. PMID: 24453215 Free PMC article.

5

A cleavable ligand column for the rapid isolation of large quantities of homogeneous and functional neurotensin receptor 1 variants from E. coli.

Egloff P, Deluigi M, Heine P, Balada S, Plückthun A. Egloff P, et al. Among authors: heine p. Protein Expr Purif. 2015 Apr;108:106-114. doi: 10.1016/j.pep.2014.10.006. Epub 2014 Oct 20. Protein Expr Purif. 2015. PMID: 25461958

6

SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.

Huber S, Casagrande F, Hug MN, Wang L, Heine P, Kummer L, Plückthun A, Hennig M. Huber S, et al. Among authors: heine p. PLoS One. 2017 May 16;12(5):e0175842. doi: 10.1371/journal.pone.0175842. eCollection 2017. PLoS One. 2017. PMID: 28510609 Free PMC article.

7

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.

Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A. Deluigi M, et al. Among authors: heine p. Sci Adv. 2021 Jan 27;7(5):eabe5504. doi: 10.1126/sciadv.abe5504. Print 2021 Jan. Sci Adv. 2021. PMID: 33571132 Free PMC article.

8

High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor.

Heine P, Witt G, Gilardi A, Gribbon P, Kummer L, Plückthun A. Heine P, et al. SLAS Discov. 2019 Oct;24(9):915-927. doi: 10.1177/2472555219837344. Epub 2019 Mar 29. SLAS Discov. 2019. PMID: 30925845 Free article.

9

Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries.

Ranganathan A, Heine P, Rudling A, Plückthun A, Kummer L, Carlsson J. Ranganathan A, et al. Among authors: heine p. ACS Chem Biol. 2017 Mar 17;12(3):735-745. doi: 10.1021/acschembio.6b00646. Epub 2017 Jan 24. ACS Chem Biol. 2017. PMID: 28032980

10

PtdIns(4,5)P₂ stabilizes active states of GPCRs and enhances selectivity of G-protein coupling.

Yen HY, Hoi KK, Liko I, Hedger G, Horrell MR, Song W, Wu D, Heine P, Warne T, Lee Y, Carpenter B, Plückthun A, Tate CG, Sansom MSP, Robinson CV. Yen HY, et al. Among authors: heine p. Nature. 2018 Jul;559(7714):423-427. doi: 10.1038/s41586-018-0325-6. Epub 2018 Jul 11. Nature. 2018. PMID: 29995853 Free PMC article.

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