Liang H - Search Results

1

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.

Szczepankiewicz BG, Liu G, Hajduk PJ, Abad-Zapatero C, Pei Z, Xin Z, Lubben TH, Trevillyan JM, Stashko MA, Ballaron SJ, Liang H, Huang F, Hutchins CW, Fesik SW, Jirousek MR. Szczepankiewicz BG, et al. Among authors: liang h. J Am Chem Soc. 2003 Apr 9;125(14):4087-96. doi: 10.1021/ja0296733. J Am Chem Soc. 2003. PMID: 12670229

2

Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

Liu G, Szczepankiewicz BG, Pei Z, Janowick DA, Xin Z, Hajduk PJ, Abad-Zapatero C, Liang H, Hutchins CW, Fesik SW, Ballaron SJ, Stashko MA, Lubben T, Mika AK, Zinker BA, Trevillyan JM, Jirousek MR. Liu G, et al. Among authors: liang h. J Med Chem. 2003 May 22;46(11):2093-103. doi: 10.1021/jm0205696. J Med Chem. 2003. PMID: 12747781

3

Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.

Liu G, Xin Z, Liang H, Abad-Zapatero C, Hajduk PJ, Janowick DA, Szczepankiewicz BG, Pei Z, Hutchins CW, Ballaron SJ, Stashko MA, Lubben TH, Berg CE, Rondinone CM, Trevillyan JM, Jirousek MR. Liu G, et al. Among authors: liang h. J Med Chem. 2003 Jul 31;46(16):3437-40. doi: 10.1021/jm034088d. J Med Chem. 2003. PMID: 12877578

4

Three-dimensional structures of proteins involved in programmed cell death.

Liang H, Fesik SW. Liang H, et al. J Mol Biol. 1997 Dec 5;274(3):291-302. doi: 10.1006/jmbi.1997.1415. J Mol Biol. 1997. PMID: 9405139 Review.

5

Equilibrium denaturation of recombinant human FK binding protein in urea.

Egan DA, Logan TM, Liang H, Matayoshi E, Fesik SW, Holzman TF. Egan DA, et al. Among authors: liang h. Biochemistry. 1993 Mar 2;32(8):1920-7. doi: 10.1021/bi00059a006. Biochemistry. 1993. PMID: 7680574

6

The secondary structure of the ets domain of human Fli-1 resembles that of the helix-turn-helix DNA-binding motif of the Escherichia coli catabolite gene activator protein.

Liang H, Olejniczak ET, Mao X, Nettesheim DG, Yu L, Thompson CB, Fesik SW. Liang H, et al. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11655-9. doi: 10.1073/pnas.91.24.11655. Proc Natl Acad Sci U S A. 1994. PMID: 7972119 Free PMC article.

7

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Huth JR, Olejniczak ET, Mendoza R, Liang H, Harris EA, Lupher ML Jr, Wilson AE, Fesik SW, Staunton DE. Huth JR, et al. Among authors: liang h. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5231-6. doi: 10.1073/pnas.97.10.5231. Proc Natl Acad Sci U S A. 2000. PMID: 10805782 Free PMC article.

8

Solution structure of the ets domain of Fli-1 when bound to DNA.

Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW. Liang H, et al. Nat Struct Biol. 1994 Dec;1(12):871-5. doi: 10.1038/nsb1294-871. Nat Struct Biol. 1994. PMID: 7773776

9

Solution structure of the DNA-binding domain of a human papillomavirus E2 protein: evidence for flexible DNA-binding regions.

Liang H, Petros AM, Meadows RP, Yoon HS, Egan DA, Walter K, Holzman TF, Robins T, Fesik SW. Liang H, et al. Biochemistry. 1996 Feb 20;35(7):2095-103. doi: 10.1021/bi951932w. Biochemistry. 1996. PMID: 8652551

10

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.

Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW. Muchmore SW, et al. Among authors: liang h. Nature. 1996 May 23;381(6580):335-41. doi: 10.1038/381335a0. Nature. 1996. PMID: 8692274

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