El-Agnaf OM - Search Results

1

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish.

Ross OA, McCormack R, Maxwell LD, Duguid RA, Quinn DJ, Barnett YA, Rea IM, El-Agnaf OM, Gibson JM, Wallace A, Middleton D, Curran MD. Ross OA, et al. Exp Gerontol. 2003 Apr;38(4):397-405. doi: 10.1016/s0531-5565(02)00266-8. Exp Gerontol. 2003. PMID: 12670626

2

A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish.

Ross OA, Awayn NH, McWhinney D, Maxwell LD, El-Agnaf OM, Barnett YA, Rea IM, Middleton D, Wallace A, Gibson JM, Curran MD. Ross OA, et al. Neuroreport. 2002 Sep 16;13(13):1621-5. doi: 10.1097/00001756-200209160-00010. Neuroreport. 2002. PMID: 12352614

3

Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.

El-Agnaf OM, Curran MD, Wallace A, Middleton D, Murgatroyd C, Curtis A, Perry R, Jaros E. El-Agnaf OM, et al. Neuroreport. 1998 Dec 1;9(17):3925-7. doi: 10.1097/00001756-199812010-00029. Neuroreport. 1998. PMID: 9875730

4

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.

El-Agnaf OM, Jakes R, Curran MD, Wallace A. El-Agnaf OM, et al. FEBS Lett. 1998 Nov 27;440(1-2):67-70. doi: 10.1016/s0014-5793(98)01419-7. FEBS Lett. 1998. PMID: 9862427 Free article.

5

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.

El-Agnaf OM, Jakes R, Curran MD, Middleton D, Ingenito R, Bianchi E, Pessi A, Neill D, Wallace A. El-Agnaf OM, et al. FEBS Lett. 1998 Nov 27;440(1-2):71-5. doi: 10.1016/s0014-5793(98)01418-5. FEBS Lett. 1998. PMID: 9862428 Free article.

6

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.

El-Agnaf OM, Salem SA, Paleologou KE, Cooper LJ, Fullwood NJ, Gibson MJ, Curran MD, Court JA, Mann DM, Ikeda S, Cookson MR, Hardy J, Allsop D. El-Agnaf OM, et al. FASEB J. 2003 Oct;17(13):1945-7. doi: 10.1096/fj.03-0098fje. Epub 2003 Aug 15. FASEB J. 2003. PMID: 14519670

7

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.

El-Agnaf OM, Salem SA, Paleologou KE, Curran MD, Gibson MJ, Court JA, Schlossmacher MG, Allsop D. El-Agnaf OM, et al. FASEB J. 2006 Mar;20(3):419-25. doi: 10.1096/fj.03-1449com. FASEB J. 2006. PMID: 16507759

8

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.

Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM. Irvine GB, et al. Mol Med. 2008 Jul-Aug;14(7-8):451-64. doi: 10.2119/2007-00100.Irvine. Mol Med. 2008. PMID: 18368143 Free PMC article. Review.

9

The N-terminal region of non-A beta component of Alzheimer's disease amyloid is responsible for its tendency to assume beta-sheet and aggregate to form fibrils.

El-Agnaf OM, Bodles AM, Guthrie DJ, Harriott P, Irvine GB. El-Agnaf OM, et al. Eur J Biochem. 1998 Nov 15;258(1):157-63. doi: 10.1046/j.1432-1327.1998.2580157.x. Eur J Biochem. 1998. PMID: 9851705 Free article.

10

Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.

Tabner BJ, Turnbull S, El-Agnaf OM, Allsop D. Tabner BJ, et al. Free Radic Biol Med. 2002 Jun 1;32(11):1076-83. doi: 10.1016/s0891-5849(02)00801-8. Free Radic Biol Med. 2002. PMID: 12031892 Review.

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