Jackson LK - Search Results

1

X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility.

Jackson LK, Goldsmith EJ, Phillips MA. Jackson LK, et al. J Biol Chem. 2003 Jun 13;278(24):22037-43. doi: 10.1074/jbc.M300188200. Epub 2003 Apr 2. J Biol Chem. 2003. PMID: 12672797 Free article.

2

Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397.

Jackson LK, Brooks HB, Myers DP, Phillips MA. Jackson LK, et al. Biochemistry. 2003 Mar 18;42(10):2933-40. doi: 10.1021/bi026795z. Biochemistry. 2003. PMID: 12627959

3

Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase.

Jackson LK, Baldwin J, Akella R, Goldsmith EJ, Phillips MA. Jackson LK, et al. Biochemistry. 2004 Oct 19;43(41):12990-9. doi: 10.1021/bi048933l. Biochemistry. 2004. PMID: 15476392

4

Altering the reaction specificity of eukaryotic ornithine decarboxylase.

Jackson LK, Brooks HB, Osterman AL, Goldsmith EJ, Phillips MA. Jackson LK, et al. Biochemistry. 2000 Sep 19;39(37):11247-57. doi: 10.1021/bi001209s. Biochemistry. 2000. PMID: 10985770

5

Long-range interactions in the dimer interface of ornithine decarboxylase are important for enzyme function.

Myers DP, Jackson LK, Ipe VG, Murphy GE, Phillips MA. Myers DP, et al. Among authors: jackson lk. Biochemistry. 2001 Nov 6;40(44):13230-6. doi: 10.1021/bi0155908. Biochemistry. 2001. PMID: 11683631

6

Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps.

Osterman AL, Brooks HB, Jackson L, Abbott JJ, Phillips MA. Osterman AL, et al. Biochemistry. 1999 Sep 7;38(36):11814-26. doi: 10.1021/bi9906221. Biochemistry. 1999. PMID: 10512638

7

Target validation for drug discovery in parasitic organisms.

Jackson LK, Phillips MA. Jackson LK, et al. Curr Top Med Chem. 2002 May;2(5):425-38. doi: 10.2174/1568026024607445. Curr Top Med Chem. 2002. PMID: 11966465 Review.

8

WNKs are potassium-sensitive kinases.

Pleinis JM, Norrell L, Akella R, Humphreys JM, He H, Sun Q, Zhang F, Sosa-Pagan J, Morrison DE, Schellinger JN, Jackson LK, Goldsmith EJ, Rodan AR. Pleinis JM, et al. Among authors: jackson lk. Am J Physiol Cell Physiol. 2021 May 1;320(5):C703-C721. doi: 10.1152/ajpcell.00456.2020. Epub 2021 Jan 13. Am J Physiol Cell Physiol. 2021. PMID: 33439774 Free PMC article.

9

Structural basis for leucine-rich nuclear export signal recognition by CRM1.

Dong X, Biswas A, Süel KE, Jackson LK, Martinez R, Gu H, Chook YM. Dong X, et al. Among authors: jackson lk. Nature. 2009 Apr 30;458(7242):1136-41. doi: 10.1038/nature07975. Epub 2009 Apr 1. Nature. 2009. PMID: 19339969 Free PMC article.

10

Buprenorphine Use for Analgesia in Palliative Care.

Jackson LK, Poon IO, Garcia MA, Imam S, Braun UK. Jackson LK, et al. Pharmacy (Basel). 2024 May 13;12(3):78. doi: 10.3390/pharmacy12030078. Pharmacy (Basel). 2024. PMID: 38804470 Free PMC article.

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