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Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling.
Dormond O, Bezzi M, Mariotti A, Ruegg C. Dormond O, et al. Among authors: ruegg c. J Biol Chem. 2002 Nov 29;277(48):45838-46. doi: 10.1074/jbc.M209213200. Epub 2002 Sep 16. J Biol Chem. 2002. PMID: 12237321 Free article.
We have recently reported that the inhibition of endothelial cell COX-2 by non-steroidal anti-inflammatory drugs suppresses alpha(V)beta(3)- (but not alpha(5)beta(1)-) dependent Rac activation, endothelial cell spreading, migration, and angiogenesis (Dormond, O., Foletti, A., Par …
We have recently reported that the inhibition of endothelial cell COX-2 by non-steroidal anti-inflammatory drugs suppresses alpha(V)beta(3)- …
Integrin-mediated adhesion and soluble ligand binding stabilize COX-2 protein levels in endothelial cells by inducing expression and preventing degradation.
Zaric J, Rüegg C. Zaric J, et al. Among authors: ruegg c. J Biol Chem. 2005 Jan 14;280(2):1077-85. doi: 10.1074/jbc.M410006200. Epub 2004 Nov 3. J Biol Chem. 2005. PMID: 15525653 Free article.
We have previously demonstrated that endothelial cell COX-2 is required for integrin alphaVbeta3-dependent activation of Rac-1 and Cdc-42 and for endothelial cell spreading, migration, and angiogenesis (Dormond, O., Foletti, A., Paroz, C., and Ruegg, C. (2001 …
We have previously demonstrated that endothelial cell COX-2 is required for integrin alphaVbeta3-dependent activation of Rac-1 and Cdc-42 an …
Proangiogenic factor PlGF programs CD11b(+) myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors.
Laurent J, Hull EF, Touvrey C, Kuonen F, Lan Q, Lorusso G, Doucey MA, Ciarloni L, Imaizumi N, Alghisi GC, Fagiani E, Zaman K, Stupp R, Shibuya M, Delaloye JF, Christofori G, Ruegg C. Laurent J, et al. Among authors: ruegg c. Cancer Res. 2011 Jun 1;71(11):3781-91. doi: 10.1158/0008-5472.CAN-10-3684. Epub 2011 Apr 20. Cancer Res. 2011. PMID: 21507936
Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches.
Guex N, Crespo I, Bron S, Ifticene-Treboux A, Faes-Van't Hull E, Kharoubi S, Liechti R, Werffeli P, Ibberson M, Majo F, Nicolas M, Laurent J, Garg A, Zaman K, Lehr HA, Stevenson BJ, Rüegg C, Coukos G, Delaloye JF, Xenarios I, Doucey MA. Guex N, et al. Among authors: ruegg c. PLoS Comput Biol. 2015 Mar 13;11(3):e1004050. doi: 10.1371/journal.pcbi.1004050. eCollection 2015 Mar. PLoS Comput Biol. 2015. PMID: 25768678 Free PMC article.
250 results