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Page 1
Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.
Hichiya H, Tanaka-Kagawa T, Soyama A, Jinno H, Koyano S, Katori N, Matsushima E, Uchiyama S, Tokunaga H, Kimura H, Minami N, Katoh M, Sugai K, Goto Y, Tamura T, Yamamoto N, Ohe Y, Kunitoh H, Nokihara H, Yoshida T, Minami H, Saijo N, Ando M, Ozawa S, Saito Y, Sawada J. Hichiya H, et al. Among authors: minami n, minami h. Drug Metab Dispos. 2005 May;33(5):630-6. doi: 10.1124/dmd.105.003830. Epub 2005 Feb 16. Drug Metab Dispos. 2005. PMID: 15716363
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Kubo T, Kim SR, Sai K, Saito Y, Nakajima T, Matsumoto K, Saito H, Shirao K, Yamamoto N, Minami H, Ohtsu A, Yoshida T, Saijo N, Ohno Y, Ozawa S, Sawada J. Kubo T, et al. Among authors: minami h. Drug Metab Dispos. 2005 Oct;33(10):1482-7. doi: 10.1124/dmd.105.005587. Epub 2005 Jul 20. Drug Metab Dispos. 2005. PMID: 16033949
Haplotypes and a novel defective allele of CES2 found in a Japanese population.
Kim SR, Sai K, Tanaka-Kagawa T, Jinno H, Ozawa S, Kaniwa N, Saito Y, Akasawa A, Matsumoto K, Saito H, Kamatani N, Shirao K, Yamamoto N, Yoshida T, Minami H, Ohtsu A, Saijo N, Sawada J. Kim SR, et al. Among authors: minami h. Drug Metab Dispos. 2007 Oct;35(10):1865-72. doi: 10.1124/dmd.107.015339. Epub 2007 Jul 19. Drug Metab Dispos. 2007. PMID: 17640957 Clinical Trial.
Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese.
Saito Y, Sai K, Maekawa K, Kaniwa N, Shirao K, Hamaguchi T, Yamamoto N, Kunitoh H, Ohe Y, Yamada Y, Tamura T, Yoshida T, Minami H, Ohtsu A, Matsumura Y, Saijo N, Sawada J. Saito Y, et al. Among authors: minami h. Drug Metab Dispos. 2009 Feb;37(2):272-6. doi: 10.1124/dmd.108.024208. Epub 2008 Nov 3. Drug Metab Dispos. 2009. PMID: 18981166
Three novel single nucleotide polymorphisms in UGT1A10.
Saeki M, Ozawa S, Saito Y, Jinno H, Hamaguchi T, Nokihara H, Shimada Y, Kunitoh H, Yamamoto N, Ohe Y, Yamada Y, Shirao K, Muto M, Mera K, Goto K, Ohmatsu H, Kubota K, Niho S, Kakinuma R, Minami H, Ohtsu A, Yoshida T, Saijo N, Sawada J. Saeki M, et al. Among authors: minami h. Drug Metab Pharmacokinet. 2002;17(5):488-90. doi: 10.2133/dmpk.17.488. Drug Metab Pharmacokinet. 2002. PMID: 15618702 Free article.
Haplotype structures of the UGT1A gene complex in a Japanese population.
Saeki M, Saito Y, Jinno H, Sai K, Ozawa S, Kurose K, Kaniwa N, Komamura K, Kotake T, Morishita H, Kamakura S, Kitakaze M, Tomoike H, Shirao K, Tamura T, Yamamoto N, Kunitoh H, Hamaguchi T, Yoshida T, Kubota K, Ohtsu A, Muto M, Minami H, Saijo N, Kamatani N, Sawada JI. Saeki M, et al. Among authors: minami h. Pharmacogenomics J. 2006 Jan-Feb;6(1):63-75. doi: 10.1038/sj.tpj.6500335. Pharmacogenomics J. 2006. PMID: 16314888
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.
Sai K, Saeki M, Saito Y, Ozawa S, Katori N, Jinno H, Hasegawa R, Kaniwa N, Sawada J, Komamura K, Ueno K, Kamakura S, Kitakaze M, Kitamura Y, Kamatani N, Minami H, Ohtsu A, Shirao K, Yoshida T, Saijo N. Sai K, et al. Among authors: minami h. Clin Pharmacol Ther. 2004 Jun;75(6):501-15. doi: 10.1016/j.clpt.2004.01.010. Clin Pharmacol Ther. 2004. PMID: 15179405
1,217 results