Morishima-Kawashima M - Search Results

1

Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.

Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Sato T, et al. J Biol Chem. 2003 Jul 4;278(27):24294-301. doi: 10.1074/jbc.M211161200. Epub 2003 Apr 21. J Biol Chem. 2003. PMID: 12707272 Free article.

2

Alzheimer's disease: beta-Amyloid protein and tau.

Morishima-Kawashima M, Ihara Y. Morishima-Kawashima M, et al. J Neurosci Res. 2002 Nov 1;70(3):392-401. doi: 10.1002/jnr.10355. J Neurosci Res. 2002. PMID: 12391602 Review.

3

Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.

Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y. Qi Y, et al. Biochemistry. 2003 Feb 4;42(4):1042-52. doi: 10.1021/bi0267590. Biochemistry. 2003. PMID: 12549925

4

Gamma-secretase activity is present in rafts but is not cholesterol-dependent.

Wada S, Morishima-Kawashima M, Qi Y, Misono H, Shimada Y, Ohno-Iwashita Y, Ihara Y. Wada S, et al. Biochemistry. 2003 Dec 2;42(47):13977-86. doi: 10.1021/bi034904j. Biochemistry. 2003. PMID: 14636066

5

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y. Funamoto S, et al. Biochemistry. 2004 Oct 26;43(42):13532-40. doi: 10.1021/bi049399k. Biochemistry. 2004. PMID: 15491160

6

Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawashima M, Ihara Y. Sato T, et al. FEBS Lett. 2005 May 23;579(13):2907-12. doi: 10.1016/j.febslet.2005.04.037. FEBS Lett. 2005. PMID: 15890346 Free article.

7

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

Yagishita S, Morishima-Kawashima M, Tanimura Y, Ishiura S, Ihara Y. Yagishita S, et al. Biochemistry. 2006 Mar 28;45(12):3952-60. doi: 10.1021/bi0521846. Biochemistry. 2006. PMID: 16548522

8

Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains.

Yagishita S, Morishima-Kawashima M, Ishiura S, Ihara Y. Yagishita S, et al. J Biol Chem. 2008 Jan 11;283(2):733-8. doi: 10.1074/jbc.M707103200. Epub 2007 Nov 16. J Biol Chem. 2008. PMID: 18024430 Free article.

9

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A. Shimojo M, et al. Among authors: morishima kawashima m. J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21. J Biol Chem. 2008. PMID: 18430735 Free article.

10

γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.

Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M. Matsumura N, et al. Among authors: morishima kawashima m. J Biol Chem. 2014 Feb 21;289(8):5109-21. doi: 10.1074/jbc.M113.510131. Epub 2013 Dec 28. J Biol Chem. 2014. PMID: 24375443 Free PMC article.

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