Middleton D - Search Results

1

Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants.

Rea IM, Ross OA, Armstrong M, McNerlan S, Alexander DH, Curran MD, Middleton D. Rea IM, et al. Among authors: middleton d. Mech Ageing Dev. 2003 Apr;124(4):555-61. doi: 10.1016/s0047-6374(03)00036-8. Mech Ageing Dev. 2003. PMID: 12714267

2

Study of age-association with cytokine gene polymorphisms in an aged Irish population.

Ross OA, Curran MD, Meenagh A, Williams F, Barnett YA, Middleton D, Rea IM. Ross OA, et al. Among authors: middleton d. Mech Ageing Dev. 2003 Feb;124(2):199-206. doi: 10.1016/s0047-6374(02)00132-x. Mech Ageing Dev. 2003. PMID: 12633940

3

HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish.

Ross OA, Curran MD, Rea IM, Hyland P, Duggan O, Barnett CR, Annett K, Patterson C, Barnett YA, Middleton D. Ross OA, et al. Among authors: middleton d. Mech Ageing Dev. 2003 Apr;124(4):563-7. doi: 10.1016/s0047-6374(03)00037-x. Mech Ageing Dev. 2003. PMID: 12714268

4

Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish.

Ross OA, O'Neill C, Rea IM, Lynch T, Gosal D, Wallace A, Curran MD, Middleton D, Gibson JM. Ross OA, et al. Among authors: middleton d. Hum Immunol. 2004 Apr;65(4):340-6. doi: 10.1016/j.humimm.2004.01.015. Hum Immunol. 2004. PMID: 15120188

5

Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study.

Rea IM, McNerlan SE, Archbold GP, Middleton D, Curran MD, Young IS, Ross OA. Rea IM, et al. Among authors: middleton d. Age (Dordr). 2013 Aug;35(4):1445-56. doi: 10.1007/s11357-012-9444-4. Epub 2012 Jul 10. Age (Dordr). 2013. PMID: 22777651 Free PMC article.

6

Killer Immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST).

Rea IM, Maxwell LD, McNerlan SE, Alexander HD, Curran MD, Middleton D, Ross OA. Rea IM, et al. Among authors: middleton d. Immun Ageing. 2013 Aug 19;10(1):35. doi: 10.1186/1742-4933-10-35. Immun Ageing. 2013. PMID: 23957956 Free PMC article.

7

A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish.

Ross OA, Awayn NH, McWhinney D, Maxwell LD, El-Agnaf OM, Barnett YA, Rea IM, Middleton D, Wallace A, Gibson JM, Curran MD. Ross OA, et al. Among authors: middleton d. Neuroreport. 2002 Sep 16;13(13):1621-5. doi: 10.1097/00001756-200209160-00010. Neuroreport. 2002. PMID: 12352614

8

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish.

Ross OA, McCormack R, Maxwell LD, Duguid RA, Quinn DJ, Barnett YA, Rea IM, El-Agnaf OM, Gibson JM, Wallace A, Middleton D, Curran MD. Ross OA, et al. Among authors: middleton d. Exp Gerontol. 2003 Apr;38(4):397-405. doi: 10.1016/s0531-5565(02)00266-8. Exp Gerontol. 2003. PMID: 12670626

9

Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population.

Ross OA, Curran MD, Crum KA, Rea IM, Barnett YA, Middleton D. Ross OA, et al. Among authors: middleton d. Exp Gerontol. 2003 May;38(5):561-5. doi: 10.1016/s0531-5565(03)00006-8. Exp Gerontol. 2003. PMID: 12742533

10

Investigation of KIR diversity in immunosenescence and longevity within the Irish population.

Maxwell LD, Ross OA, Curran MD, Rea IM, Middleton D. Maxwell LD, et al. Among authors: middleton d. Exp Gerontol. 2004 Aug;39(8):1223-32. doi: 10.1016/j.exger.2004.05.003. Exp Gerontol. 2004. PMID: 15288696

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