Schleim KD - Search Results

1

Substituted bridged phenyl piperidines: orally active growth hormone secretagogues.

Lu Z, Tata JR, Cheng K, Wei L, Chan WW, Butler B, Schleim KD, Jacks TM, Hickey G, Patchett AA. Lu Z, et al. Among authors: schleim kd. Bioorg Med Chem Lett. 2003 May 19;13(10):1817-20. doi: 10.1016/s0960-894x(03)00261-0. Bioorg Med Chem Lett. 2003. PMID: 12729672

2

Highly potent growth hormone secretagogues.

Lu Z, Tata JR, Cheng K, Wei L, Chan WW, Butler B, Schleim KD, Jacks TM, Hickey G, Patchett AA. Lu Z, et al. Among authors: schleim kd. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3657-9. doi: 10.1016/j.bmcl.2007.04.050. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17482461

3

A potent, orally bioavailable benzazepinone growth hormone secretagogue.

DeVita RJ, Bochis R, Frontier AJ, Kotliar A, Fisher MH, Schoen WR, Wyvratt MJ, Cheng K, Chan WW, Butler B, Jacks TM, Hickey GJ, Schleim KD, Leung K, Chen Z, Chiu SL, Feeney WP, Cunningham PK, Smith RG. DeVita RJ, et al. Among authors: schleim kd. J Med Chem. 1998 May 7;41(10):1716-28. doi: 10.1021/jm970816j. J Med Chem. 1998. PMID: 9572898

4

1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue.

Yang L, Morriello G, Patchett AA, Leung K, Jacks T, Cheng K, Schleim KD, Feeney W, Chan WW, Chiu SH, Smith RG. Yang L, et al. Among authors: schleim kd. J Med Chem. 1998 Jul 2;41(14):2439-41. doi: 10.1021/jm9800191. J Med Chem. 1998. PMID: 9651148 No abstract available.

5

Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues.

Barakat KJ, Cheng K, Chan WW, Butler BS, Jacks TM, Schleim KD, Hora DF Jr, Hickey GJ, Smith RG, Patchett AA, Nargund RP. Barakat KJ, et al. Among authors: schleim kd. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1431-6. doi: 10.1016/s0960-894x(98)00238-8. Bioorg Med Chem Lett. 1998. PMID: 9871779

6

Potent 3-spiropiperidine growth hormone secretagogues.

Yang L, Morriello G, Prendergast K, Cheng K, Jacks T, Chan WW, Schleim KD, Smith RG, Patchett AA. Yang L, et al. Among authors: schleim kd. Bioorg Med Chem Lett. 1998 Jan 6;8(1):107-12. doi: 10.1016/s0960-894x(97)10199-8. Bioorg Med Chem Lett. 1998. PMID: 9925440

7

Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.

Pasternak A, Pan Y, Marino D, Sanderson PE, Mosley R, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L. Pasternak A, et al. Among authors: schleim kd. Bioorg Med Chem Lett. 1999 Feb 8;9(3):491-6. doi: 10.1016/s0960-894x(99)00016-5. Bioorg Med Chem Lett. 1999. PMID: 10091708

8

Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues.

Yang L, Morriello G, Leung K, Jacks T, Cheng K, Schleim KD, Smith R, Patchett AA. Yang L, et al. Among authors: schleim kd. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1761-6. doi: 10.1016/s0960-894x(99)00286-3. Bioorg Med Chem Lett. 1999. PMID: 10406638

9

Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.

Zhou C, Guo L, Morriello G, Pasternak A, Pan Y, Rohrer SP, Birzin ET, Huskey SE, Jacks T, Schleim KD, Cheng K, Schaeffer JM, Patchett AA, Yang L. Zhou C, et al. Among authors: schleim kd. Bioorg Med Chem Lett. 2001 Feb 12;11(3):415-7. doi: 10.1016/s0960-894x(00)00687-9. Bioorg Med Chem Lett. 2001. PMID: 11212124

10

MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles.

Jacks T, Smith R, Judith F, Schleim K, Frazier E, Chen H, Krupa D, Hora D Jr, Nargund R, Patchett A, Hickey G. Jacks T, et al. Endocrinology. 1996 Dec;137(12):5284-9. doi: 10.1210/endo.137.12.8940347. Endocrinology. 1996. PMID: 8940347

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