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A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila.
Apostol BL, Kazantsev A, Raffioni S, Illes K, Pallos J, Bodai L, Slepko N, Bear JE, Gertler FB, Hersch S, Housman DE, Marsh JL, Thompson LM. Apostol BL, et al. Among authors: illes k. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5950-5. doi: 10.1073/pnas.2628045100. Epub 2003 May 1. Proc Natl Acad Sci U S A. 2003. PMID: 12730384 Free PMC article.
SUMO modification of Huntingtin and Huntington's disease pathology.
Steffan JS, Agrawal N, Pallos J, Rockabrand E, Trotman LC, Slepko N, Illes K, Lukacsovich T, Zhu YZ, Cattaneo E, Pandolfi PP, Thompson LM, Marsh JL. Steffan JS, et al. Among authors: illes k. Science. 2004 Apr 2;304(5667):100-4. doi: 10.1126/science.1092194. Science. 2004. PMID: 15064418
CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S, Cattaneo E, Marsh JL, Thompson LM. Apostol BL, et al. Among authors: illes k. Mol Cell Neurosci. 2008 Sep;39(1):8-20. doi: 10.1016/j.mcn.2008.04.007. Epub 2008 Apr 24. Mol Cell Neurosci. 2008. PMID: 18602275
We previously reported that mutant Htt expression activates the ERK1/2 and JNK pathways [Apostol, B.L., Illes, K., Pallos, J., Bodai, L., Wu, J., Strand, A., Schweitzer, E.S., Olson, J.M., Kazantsev, A., Marsh, J.L., Thompson, L.M., 2006. ...
We previously reported that mutant Htt expression activates the ERK1/2 and JNK pathways [Apostol, B.L., Illes, K., Pallos, J., …
SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.
O'Rourke JG, Gareau JR, Ochaba J, Song W, Raskó T, Reverter D, Lee J, Monteys AM, Pallos J, Mee L, Vashishtha M, Apostol BL, Nicholson TP, Illes K, Zhu YZ, Dasso M, Bates GP, Difiglia M, Davidson B, Wanker EE, Marsh JL, Lima CD, Steffan JS, Thompson LM. O'Rourke JG, et al. Among authors: illes k. Cell Rep. 2013 Jul 25;4(2):362-75. doi: 10.1016/j.celrep.2013.06.034. Epub 2013 Jul 18. Cell Rep. 2013. PMID: 23871671 Free PMC article.
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. Thompson LM, et al. Among authors: illes k. J Cell Biol. 2009 Dec 28;187(7):1083-99. doi: 10.1083/jcb.200909067. Epub 2009 Dec 21. J Cell Biol. 2009. PMID: 20026656 Free PMC article.
Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Gorelik A, Gebai A, Illes K, Piomelli D, Nagar B. Gorelik A, et al. Among authors: illes k. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10032-E10040. doi: 10.1073/pnas.1811759115. Epub 2018 Oct 9. Proc Natl Acad Sci U S A. 2018. PMID: 30301806 Free PMC article.
Crystal structure of the mammalian lipopolysaccharide detoxifier.
Gorelik A, Illes K, Nagar B. Gorelik A, et al. Among authors: illes k. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E896-E905. doi: 10.1073/pnas.1719834115. Epub 2018 Jan 17. Proc Natl Acad Sci U S A. 2018. PMID: 29343645 Free PMC article.
Crystal structure of mammalian acid sphingomyelinase.
Gorelik A, Illes K, Heinz LX, Superti-Furga G, Nagar B. Gorelik A, et al. Among authors: illes k. Nat Commun. 2016 Jul 20;7:12196. doi: 10.1038/ncomms12196. Nat Commun. 2016. PMID: 27435900 Free PMC article.
42 results