Braña AF - Search Results

1

Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.

Remsing LL, González AM, Nur-e-Alam M, Fernández-Lozano MJ, Braña AF, Rix U, Oliveira MA, Méndez C, Salas JA, Rohr J. Remsing LL, et al. Among authors: brana af. J Am Chem Soc. 2003 May 14;125(19):5745-53. doi: 10.1021/ja034162h. J Am Chem Soc. 2003. PMID: 12733914 Free PMC article.

2

Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.

Lombó F, Siems K, Braña AF, Méndez C, Bindseil K, Salas JA. Lombó F, et al. Among authors: brana af. J Bacteriol. 1997 May;179(10):3354-7. doi: 10.1128/jb.179.10.3354-3357.1997. J Bacteriol. 1997. PMID: 9150235 Free PMC article.

3

Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.

Fernández E, Weissbach U, Sánchez Reillo C, Braña AF, Méndez C, Rohr J, Salas JA. Fernández E, et al. Among authors: brana af. J Bacteriol. 1998 Sep;180(18):4929-37. doi: 10.1128/JB.180.18.4929-4937.1998. J Bacteriol. 1998. PMID: 9733697 Free PMC article.

4

The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster.

Lombó F, Braña AF, Méndez C, Salas JA. Lombó F, et al. Among authors: brana af. J Bacteriol. 1999 Jan;181(2):642-7. doi: 10.1128/JB.181.2.642-647.1999. J Bacteriol. 1999. PMID: 9882681 Free PMC article.

5

Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.

Prado L, Fernández E, Weissbach U, Blanco G, Quirós LM, Braña AF, Méndez C, Rohr J, Salas JA. Prado L, et al. Among authors: brana af. Chem Biol. 1999 Jan;6(1):19-30. doi: 10.1016/s1074-5521(99)80017-9. Chem Biol. 1999. PMID: 9889148

6

Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.

Prado L, Lombó F, Braña AF, Méndez C, Rohr J, Salas JA. Prado L, et al. Among authors: brana af. Mol Gen Genet. 1999 Mar;261(2):216-25. doi: 10.1007/s004380050960. Mol Gen Genet. 1999. PMID: 10102355

7

Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.

Lozano MJ, Remsing LL, Quirós LM, Braña AF, Fernández E, Sánchez C, Méndez C, Rohr J, Salas JA. Lozano MJ, et al. Among authors: brana af. J Biol Chem. 2000 Feb 4;275(5):3065-74. doi: 10.1074/jbc.275.5.3065. J Biol Chem. 2000. PMID: 10652287 Free article.

8

Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.

Blanco G, Fernández E, Fernández MJ, Braña AF, Weissbach U, Künzel E, Rohr J, Méndez C, Salas JA. Blanco G, et al. Among authors: brana af. Mol Gen Genet. 2000 Jan;262(6):991-1000. doi: 10.1007/pl00008667. Mol Gen Genet. 2000. PMID: 10660060

9

Glycosylation of macrolide antibiotics. Purification and kinetic studies of a macrolide glycosyltransferase from Streptomyces antibioticus.

Quirós LM, Carbajo RJ, Braña AF, Salas JA. Quirós LM, et al. Among authors: brana af. J Biol Chem. 2000 Apr 21;275(16):11713-20. doi: 10.1074/jbc.275.16.11713. J Biol Chem. 2000. PMID: 10766792 Free article.

10

Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.

Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Braña AF, Méndez C, Salas JA. Aguirrezabalaga I, et al. Among authors: brana af. Antimicrob Agents Chemother. 2000 May;44(5):1266-75. doi: 10.1128/AAC.44.5.1266-1275.2000. Antimicrob Agents Chemother. 2000. PMID: 10770761 Free PMC article.

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