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Page 1
The design of potent, non-peptidic inhibitors of hepatitis C protease.
Andrews DM, Chaignot HM, Coomber BA, Dowle MD, Hind SL, Johnson MR, Jones PS, Mills G, Patikis A, Pateman TJ, Robinson JE, Slater MJ, Trivedi N. Andrews DM, et al. Among authors: chaignot hm. Eur J Med Chem. 2003 Apr;38(4):339-43. doi: 10.1016/s0223-5234(03)00050-3. Eur J Med Chem. 2003. PMID: 12750019
The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.
Giblin GM, Bit RA, Brown SH, Chaignot HM, Chowdhury A, Chessell IP, Clayton NM, Coleman T, Hall A, Hammond B, Hurst DN, Michel AD, Naylor A, Novelli R, Scoccitti T, Spalding D, Tang SP, Wilson AW, Wilson R. Giblin GM, et al. Among authors: chaignot hm. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. doi: 10.1016/j.bmcl.2006.10.041. Epub 2006 Oct 20. Bioorg Med Chem Lett. 2007. PMID: 17084082
Discovery of novel biaryl heterocyclic EP1 receptor antagonists.
Hall A, Bit RA, Brown SH, Chaignot HM, Chessell IP, Coleman T, Giblin GM, Hurst DN, Kilford IR, Lewell XQ, Michel AD, Mohamed S, Naylor A, Novelli R, Skinner L, Spalding DJ, Tang SP, Wilson RJ. Hall A, et al. Among authors: chaignot hm. Bioorg Med Chem Lett. 2006 May 15;16(10):2666-71. doi: 10.1016/j.bmcl.2006.02.014. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503138