Najajreh Y - Search Results

1

DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.

Kasparkova J, Marini V, Najajreh Y, Gibson D, Brabec V. Kasparkova J, et al. Among authors: najajreh y. Biochemistry. 2003 May 27;42(20):6321-32. doi: 10.1021/bi0342315. Biochemistry. 2003. PMID: 12755637

2

Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action.

Kasparkova J, Novakova O, Marini V, Najajreh Y, Gibson D, Perez JM, Brabec V. Kasparkova J, et al. Among authors: najajreh y. J Biol Chem. 2003 Nov 28;278(48):47516-25. doi: 10.1074/jbc.M304720200. Epub 2003 Sep 10. J Biol Chem. 2003. PMID: 12970368 Free article.

We reported recently (Kasparkova, J., Marini, V., Najajreh, Y., Gibson, D., and Brabec, V. (2003) Biochemistry 42, 6321-6332) that the replacement of one ammine ligand by the heterocyclic ligand, such as piperidine, piperazine, or 4-picoline in the molecule of trans …

We reported recently (Kasparkova, J., Marini, V., Najajreh, Y., Gibson, D., and Brabec, V. (2003) Biochemistry 42, 6321-6332) …

3

Effects of a piperidine ligand on DNA modification by antitumor cisplatin analogues.

Kasparkova J, Novakova O, Najajreh Y, Gibson D, Perez JM, Brabec V. Kasparkova J, et al. Among authors: najajreh y. Chem Res Toxicol. 2003 Nov;16(11):1424-32. doi: 10.1021/tx034128g. Chem Res Toxicol. 2003. PMID: 14615968

4

DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans,trans-[{PtCl2(NH3)}2(piperazine)].

Brabec V, Christofis P, Slámová M, Kostrhunová H, Nováková O, Najajreh Y, Gibson D, Kaspárková J. Brabec V, et al. Among authors: najajreh y. Biochem Pharmacol. 2007 Jun 15;73(12):1887-900. doi: 10.1016/j.bcp.2007.03.003. Epub 2007 Mar 12. Biochem Pharmacol. 2007. PMID: 17400194

5

Interactions of cisplatin and transplatin with proteins. Comparison of binding kinetics, binding sites and reactivity of the Pt-protein adducts of cisplatin and transplatin towards biological nucleophiles.

Peleg-Shulman T, Najajreh Y, Gibson D. Peleg-Shulman T, et al. Among authors: najajreh y. J Inorg Biochem. 2002 Jul 25;91(1):306-11. doi: 10.1016/s0162-0134(02)00362-8. J Inorg Biochem. 2002. PMID: 12121789

6

Preparation, cytotoxicity and interactions with nucleophiles of three isomeric transplatinum complexes containing methylpiperidine ligands.

Jawbry S, Freikman I, Najajreh Y, Perez JM, Gibson D. Jawbry S, et al. Among authors: najajreh y. J Inorg Biochem. 2005 Oct;99(10):1983-91. doi: 10.1016/j.jinorgbio.2005.06.011. J Inorg Biochem. 2005. PMID: 16054219

7

Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand.

Najajreh Y, Kasparkova J, Marini V, Gibson D, Brabec V. Najajreh Y, et al. J Biol Inorg Chem. 2005 Nov;10(7):722-31. doi: 10.1007/s00775-005-0024-2. Epub 2005 Nov 8. J Biol Inorg Chem. 2005. PMID: 16208494

8

Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines.

Najajreh Y, Perez JM, Navarro-Ranninger C, Gibson D. Najajreh Y, et al. J Med Chem. 2002 Nov 21;45(24):5189-95. doi: 10.1021/jm0201969. J Med Chem. 2002. PMID: 12431046

9

Novel apoptosis-inducing trans-platinum piperidine derivatives: synthesis and biological characterization.

Khazanov E, Barenholz Y, Gibson D, Najajreh Y. Khazanov E, et al. Among authors: najajreh y. J Med Chem. 2002 Nov 21;45(24):5196-204. doi: 10.1021/jm020817y. J Med Chem. 2002. PMID: 12431047

10

Structure and unique interactions with DNA of a cationic trans-platinum complex with the nonplanar bicyclic piperidinopiperidine ligand.

Najajreh Y, Prilutski D, Ardeli-Tzaraf Y, Perez JM, Khazanov E, Barenholz Y, Kasparkova J, Brabec V, Gibson D. Najajreh Y, et al. Angew Chem Int Ed Engl. 2005 May 6;44(19):2885-7. doi: 10.1002/anie.200462389. Angew Chem Int Ed Engl. 2005. PMID: 15822135 No abstract available.

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