Smith DA - Search Results

1

The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human.

Roffey SJ, Cole S, Comby P, Gibson D, Jezequel SG, Nedderman AN, Smith DA, Walker DK, Wood N. Roffey SJ, et al. Among authors: smith da. Drug Metab Dispos. 2003 Jun;31(6):731-41. doi: 10.1124/dmd.31.6.731. Drug Metab Dispos. 2003. PMID: 12756205

2

Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV.

Walker DK, Abel S, Comby P, Muirhead GJ, Nedderman AN, Smith DA. Walker DK, et al. Among authors: smith da. Drug Metab Dispos. 2005 Apr;33(4):587-95. doi: 10.1124/dmd.104.002626. Epub 2005 Jan 13. Drug Metab Dispos. 2005. PMID: 15650075 Clinical Trial.

3

Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man.

Smith DA, Rasmussen HS, Stopher DA, Walker DK. Smith DA, et al. Xenobiotica. 1992 Jun;22(6):709-19. doi: 10.3109/00498259209053133. Xenobiotica. 1992. PMID: 1441594

4

Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.

Walker DK, Alabaster CT, Congrave GS, Hargreaves MB, Hyland R, Jones BC, Reed LJ, Smith DA. Walker DK, et al. Among authors: smith da. Drug Metab Dispos. 1996 Apr;24(4):447-55. Drug Metab Dispos. 1996. PMID: 8801060

5

Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist.

Walker DK, Dack KN, Dickinson RP, Fenner KS, James K, Rawson DJ, Smith DA. Walker DK, et al. Among authors: smith da. Drug Metab Dispos. 2001 Nov;29(11):1424-31. Drug Metab Dispos. 2001. PMID: 11602517

6

What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs.

Roffey SJ, Obach RS, Gedge JI, Smith DA. Roffey SJ, et al. Among authors: smith da. Drug Metab Rev. 2007;39(1):17-43. doi: 10.1080/03602530600952172. Drug Metab Rev. 2007. PMID: 17364879 Review.

7

Liquid-liquid extraction and high-performance liquid chromatography for the determination of a novel antidysrhythmic agent (UK-68,798) in human urine.

Walker DK, Smith DA, Stopher DA. Walker DK, et al. Among authors: smith da. J Chromatogr. 1991 Aug 23;568(2):475-80. doi: 10.1016/0378-4347(91)80186-g. J Chromatogr. 1991. PMID: 1783653

8

Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine.

Walker DK, Humphrey MJ, Smith DA. Walker DK, et al. Among authors: smith da. Xenobiotica. 1994 Mar;24(3):243-50. doi: 10.3109/00498259409043236. Xenobiotica. 1994. PMID: 8009887

9

Pharmacokinetics of a series of bis(methanesulphonamido-arylalkyl)amines in the beagle dog.

Walker DK, Beaumont KC, Stopher DA, Smith DA. Walker DK, et al. Among authors: smith da. Xenobiotica. 1996 Oct;26(10):1101-11. doi: 10.3109/00498259609167425. Xenobiotica. 1996. PMID: 8905922

10

The use of C(av) rather than AUC in safety assessment.

Smith DA, Morgan P, Vogel WM, Walker DK. Smith DA, et al. Regul Toxicol Pharmacol. 2010 Jun;57(1):70-3. doi: 10.1016/j.yrtph.2010.01.001. Epub 2010 Jan 13. Regul Toxicol Pharmacol. 2010. PMID: 20074607

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