Walker DK - Search Results

1

The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human.

Roffey SJ, Cole S, Comby P, Gibson D, Jezequel SG, Nedderman AN, Smith DA, Walker DK, Wood N. Roffey SJ, et al. Among authors: walker dk. Drug Metab Dispos. 2003 Jun;31(6):731-41. doi: 10.1124/dmd.31.6.731. Drug Metab Dispos. 2003. PMID: 12756205

2

Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV.

Walker DK, Abel S, Comby P, Muirhead GJ, Nedderman AN, Smith DA. Walker DK, et al. Drug Metab Dispos. 2005 Apr;33(4):587-95. doi: 10.1124/dmd.104.002626. Epub 2005 Jan 13. Drug Metab Dispos. 2005. PMID: 15650075 Clinical Trial.

3

Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog.

Walker DK, Beaumont KC, Comby P, Evans KM, Gedge JI, Halliday RC, Roffey SJ, Wright PA. Walker DK, et al. Xenobiotica. 2001 Aug-Sep;31(8-9):651-64. doi: 10.1080/00498250110056522. Xenobiotica. 2001. PMID: 11569531

4

Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist.

Walker DK, Dack KN, Dickinson RP, Fenner KS, James K, Rawson DJ, Smith DA. Walker DK, et al. Drug Metab Dispos. 2001 Nov;29(11):1424-31. Drug Metab Dispos. 2001. PMID: 11602517

5

Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man.

Smith DA, Rasmussen HS, Stopher DA, Walker DK. Smith DA, et al. Among authors: walker dk. Xenobiotica. 1992 Jun;22(6):709-19. doi: 10.3109/00498259209053133. Xenobiotica. 1992. PMID: 1441594

6

Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man.

Webster R, Cole S, Gedge J, Roffey S, Walker D, Wild W. Webster R, et al. Xenobiotica. 2003 May;33(5):541-60. doi: 10.1080/0049825031000085988. Xenobiotica. 2003. PMID: 12746109

7

The use of 96-well Scintiplates to facilitate definitive metabolism studies for drug candidates.

Nedderman AN, Savage ME, White KL, Walker DK. Nedderman AN, et al. Among authors: walker dk. J Pharm Biomed Anal. 2004 Feb 18;34(3):607-17. doi: 10.1016/s0731-7085(03)00575-2. J Pharm Biomed Anal. 2004. PMID: 15127817

8

Liquid-liquid extraction and high-performance liquid chromatography for the determination of a novel antidysrhythmic agent (UK-68,798) in human urine.

Walker DK, Smith DA, Stopher DA. Walker DK, et al. J Chromatogr. 1991 Aug 23;568(2):475-80. doi: 10.1016/0378-4347(91)80186-g. J Chromatogr. 1991. PMID: 1783653

9

Importance of metabolic stability and hepatic distribution to the pharmacokinetic profile of amlodipine.

Walker DK, Humphrey MJ, Smith DA. Walker DK, et al. Xenobiotica. 1994 Mar;24(3):243-50. doi: 10.3109/00498259409043236. Xenobiotica. 1994. PMID: 8009887

10

Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.

Walker DK, Alabaster CT, Congrave GS, Hargreaves MB, Hyland R, Jones BC, Reed LJ, Smith DA. Walker DK, et al. Drug Metab Dispos. 1996 Apr;24(4):447-55. Drug Metab Dispos. 1996. PMID: 8801060

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