Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism.
Sato T, Kudo T, Ikehara Y, Ogawa H, Hirano T, Kiyohara K, Hagiwara K, Togayachi A, Ema M, Takahashi S, Kimata K, Watanabe H, Narimatsu H.
Sato T, et al. Among authors: kimata k.
J Biol Chem. 2011 Feb 18;286(7):5803-12. doi: 10.1074/jbc.M110.159244. Epub 2010 Dec 10.
J Biol Chem. 2011.
PMID: 21148564
Free PMC article.
Biochemically, the level of CS in Csgalnact1(-/-) cartilage was reduced to 50% that of wild-type cartilage, whereas its chain length was similar to wild-type mice, indicating that CSGalNAcT-1 participates in the CS chain initiation as suggested in the previous study (Sakai, K …
Biochemically, the level of CS in Csgalnact1(-/-) cartilage was reduced to 50% that of wild-type cartilage, whereas its chain length was sim …