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Peptide-based, irreversible inhibitors of gamma-secretase activity.
Piper SC, Amtul Z, Galiñanes-Garcia L, Howard VG, Ziani-Cherif C, McLendon C, Rochette MJ, Fauq A, Golde TE, Murphy MP. Piper SC, et al. Among authors: rochette mj. Biochem Biophys Res Commun. 2003 Jun 6;305(3):529-33. doi: 10.1016/s0006-291x(03)00828-3. Biochem Biophys Res Commun. 2003. PMID: 12763025
Gamma-secretase: substrates and inhibitors.
Rochette MJ, Murphy MP. Rochette MJ, et al. Mol Neurobiol. 2002 Aug;26(1):81-95. doi: 10.1385/MN:26:1:081. Mol Neurobiol. 2002. PMID: 12392058
Overexpression of nicastrin increases Abeta production.
Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE. Murphy MP, et al. Among authors: rochette mj. FASEB J. 2003 Jun;17(9):1138-40. doi: 10.1096/fj.02-1050fje. Epub 2003 Apr 8. FASEB J. 2003. PMID: 12692078