Hewer A - Search Results

1

Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.

Arlt VM, Stiborova M, Hewer A, Schmeiser HH, Phillips DH. Arlt VM, et al. Among authors: hewer a. Cancer Res. 2003 Jun 1;63(11):2752-61. Cancer Res. 2003. PMID: 12782579

2

DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats.

Arlt VM, Sorg BL, Osborne M, Hewer A, Seidel A, Schmeiser HH, Phillips DH. Arlt VM, et al. Among authors: hewer a. Biochem Biophys Res Commun. 2003 Jan 3;300(1):107-14. doi: 10.1016/s0006-291x(02)02789-4. Biochem Biophys Res Commun. 2003. PMID: 12480528

3

3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.

Arlt VM, Hewer A, Sorg BL, Schmeiser HH, Phillips DH, Stiborova M. Arlt VM, et al. Among authors: hewer a. Chem Res Toxicol. 2004 Aug;17(8):1092-101. doi: 10.1021/tx049912v. Chem Res Toxicol. 2004. PMID: 15310241

4

Sex differences in the activation of tamoxifen to DNA binding species in rat liver in vivo and in rat hepatocytes in vitro: role of sulfotransferase induction.

Davis W, Hewer A, Rajkowski KM, Meinl W, Glatt H, Phillips DH. Davis W, et al. Among authors: hewer a. Cancer Res. 2000 Jun 1;60(11):2887-91. Cancer Res. 2000. PMID: 10850433

5

Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: the R-isomer forms more DNA adducts in rat liver cells.

Osborne MR, Hewer A, Phillips DH. Osborne MR, et al. Among authors: hewer a. Chem Res Toxicol. 2004 May;17(5):697-701. doi: 10.1021/tx049957w. Chem Res Toxicol. 2004. PMID: 15144227

6

Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen.

Osborne MR, Hewer A, Hardcastle IR, Carmichael PL, Phillips DH. Osborne MR, et al. Among authors: hewer a. Cancer Res. 1996 Jan 1;56(1):66-71. Cancer Res. 1996. PMID: 8548777

7

Smoking-related DNA adducts in anal epithelium.

Phillips DH, Hewer A, Scholefield JH, Skinner P. Phillips DH, et al. Among authors: hewer a. Mutat Res. 2004 Jun 13;560(2):167-72. doi: 10.1016/j.mrgentox.2004.02.014. Mutat Res. 2004. PMID: 15157654

8

32P-postlabeling analysis of DNA adducts.

Phillips DH, Hewer A, Arlt VM. Phillips DH, et al. Among authors: hewer a. Methods Mol Biol. 2005;291:3-12. doi: 10.1385/1-59259-840-4:003. Methods Mol Biol. 2005. PMID: 15502206

9

Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.

Phillips DH, Hewer A, Osborne MR, Cole KJ, Churchill C, Arlt VM. Phillips DH, et al. Among authors: hewer a. Mutagenesis. 2005 Jul;20(4):297-303. doi: 10.1093/mutage/gei038. Epub 2005 May 31. Mutagenesis. 2005. PMID: 15928012

10

N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation.

Al-Buheissi SZ, Patel HR, Meinl W, Hewer A, Bryan RL, Glatt H, Miller RA, Phillips DH. Al-Buheissi SZ, et al. Among authors: hewer a. Pharmacogenet Genomics. 2006 Jun;16(6):391-9. doi: 10.1097/01.fpc.0000204998.22301.09. Pharmacogenet Genomics. 2006. PMID: 16708048

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