Appleby TC - Search Results

1

Hepatitis C virus therapies: current treatments, targets and future perspectives.

Walker MP, Appleby TC, Zhong W, Lau JY, Hong Z. Walker MP, et al. Among authors: appleby tc. Antivir Chem Chemother. 2003 Jan;14(1):1-21. doi: 10.1177/095632020301400101. Antivir Chem Chemother. 2003. PMID: 12790512 Free article. Review.

2

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure.

Yan S, Larson G, Wu JZ, Appleby T, Ding Y, Hamatake R, Hong Z, Yao N. Yan S, et al. Bioorg Med Chem Lett. 2007 Jan 1;17(1):63-7. doi: 10.1016/j.bmcl.2006.09.095. Epub 2006 Oct 4. Bioorg Med Chem Lett. 2007. PMID: 17049849

3

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.

Yan S, Appleby T, Larson G, Wu JZ, Hamatake R, Hong Z, Yao N. Yan S, et al. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5888-91. doi: 10.1016/j.bmcl.2006.08.056. Epub 2006 Aug 24. Bioorg Med Chem Lett. 2006. PMID: 16934455

4

Isothiazoles as active-site inhibitors of HCV NS5B polymerase.

Yan S, Appleby T, Gunic E, Shim JH, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N. Yan S, et al. Bioorg Med Chem Lett. 2007 Jan 1;17(1):28-33. doi: 10.1016/j.bmcl.2006.10.002. Epub 2006 Oct 5. Bioorg Med Chem Lett. 2007. PMID: 17049853

5

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study.

Yan S, Appleby T, Larson G, Wu JZ, Hamatake RK, Hong Z, Yao N. Yan S, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1991-5. doi: 10.1016/j.bmcl.2007.01.024. Epub 2007 Jan 19. Bioorg Med Chem Lett. 2007. PMID: 17276060

6

Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative.

Appleby TC, Larson G, Cheney IW, Walker H, Wu JZ, Zhong W, Hong Z, Yao N. Appleby TC, et al. Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):278-84. doi: 10.1107/S0907444904032937. Epub 2005 Feb 24. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 15735337

7

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.

Cheney IW, Yan S, Appleby T, Walker H, Vo T, Yao N, Hamatake R, Hong Z, Wu JZ. Cheney IW, et al. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83. doi: 10.1016/j.bmcl.2006.12.086. Epub 2007 Jan 4. Bioorg Med Chem Lett. 2007. PMID: 17251021

8

Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer.

Appleby TC, Luecke H, Shim JH, Wu JZ, Cheney IW, Zhong W, Vogeley L, Hong Z, Yao N. Appleby TC, et al. J Virol. 2005 Jan;79(1):277-88. doi: 10.1128/JVI.79.1.277-288.2005. J Virol. 2005. PMID: 15596823 Free PMC article.

9

Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.

El Abdellaoui H, Varaprasad CV, Barawkar D, Chakravarty S, Maderna A, Tam R, Chen H, Allan M, Wu JZ, Appleby T, Yan S, Zhang W, Lang S, Yao N, Hamatake R, Hong Z. El Abdellaoui H, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5561-6. doi: 10.1016/j.bmcl.2006.08.048. Epub 2006 Aug 24. Bioorg Med Chem Lett. 2006. PMID: 16934458

10

An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture.

Chan K, Cheng G, Beran RK, Yang H, Appleby TC, Pokrovskii MV, Mo H, Zhong W, Delaney WE 4th. Chan K, et al. Among authors: appleby tc. Virology. 2012 Jan 20;422(2):224-34. doi: 10.1016/j.virol.2011.10.022. Epub 2011 Nov 17. Virology. 2012. PMID: 22099378 Free article.

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