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The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.
Carlomagno T, Blommers MJ, Meiler J, Jahnke W, Schupp T, Petersen F, Schinzer D, Altmann KH, Griesinger C. Carlomagno T, et al. Among authors: altmann kh. Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2511-5. doi: 10.1002/anie.200351276. Angew Chem Int Ed Engl. 2003. PMID: 12800173 No abstract available.
The binding mode of side chain- and C3-modified epothilones to tubulin.
Erdélyi M, Navarro-Vázquez A, Pfeiffer B, Kuzniewski CN, Felser A, Widmer T, Gertsch J, Pera B, Díaz JF, Altmann KH, Carlomagno T. Erdélyi M, et al. Among authors: altmann kh. ChemMedChem. 2010 Jun 7;5(6):911-20. doi: 10.1002/cmdc.201000050. ChemMedChem. 2010. PMID: 20432490
Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches.
Canales A, Nieto L, Rodríguez-Salarichs J, Sánchez-Murcia PA, Coderch C, Cortés-Cabrera A, Paterson I, Carlomagno T, Gago F, Andreu JM, Altmann KH, Jiménez-Barbero J, Díaz JF. Canales A, et al. Among authors: altmann kh. ACS Chem Biol. 2014 Apr 18;9(4):1033-43. doi: 10.1021/cb400673h. Epub 2014 Feb 25. ACS Chem Biol. 2014. PMID: 24524625 Free article.
Structural basis of microtubule stabilization by laulimalide and peloruside A.
Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Díaz JF, Steinmetz MO. Prota AE, et al. Among authors: altmann kh. Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1621-5. doi: 10.1002/anie.201307749. Epub 2014 Jan 27. Angew Chem Int Ed Engl. 2014. PMID: 24470331
176 results