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The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.
Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR Jr. Hsu T, et al. Among authors: chen m, chen b. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12420-5. doi: 10.1073/pnas.1635213100. Epub 2003 Oct 13. Proc Natl Acad Sci U S A. 2003. PMID: 14557547 Free PMC article.
Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates.
Larsen MH, Biermann K, Chen B, Hsu T, Sambandamurthy VK, Lackner AA, Aye PP, Didier P, Huang D, Shao L, Wei H, Letvin NL, Frothingham R, Haynes BF, Chen ZW, Jacobs WR Jr. Larsen MH, et al. Among authors: chen b, chen zw. Vaccine. 2009 Jul 23;27(34):4709-17. doi: 10.1016/j.vaccine.2009.05.050. Epub 2009 Jun 2. Vaccine. 2009. PMID: 19500524 Free PMC article.
Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility.
Schwebach JR, Chen B, Glatman-Freedman A, Casadevall A, McKinney JD, Harb JL, McGuire PJ, Barkley WE, Bloom BR, Jacobs WR Jr. Schwebach JR, et al. Among authors: chen b. Appl Environ Microbiol. 2002 Sep;68(9):4646-9. doi: 10.1128/AEM.68.9.4646-4649.2002. Appl Environ Microbiol. 2002. PMID: 12200325 Free PMC article.
Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.
Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, Jalapathy KV, Chen M, Kim J, Porcelli SA, Chan J, Morris SL, Jacobs WR Jr. Sambandamurthy VK, et al. Among authors: chen m, chen b. Vaccine. 2006 Sep 11;24(37-39):6309-20. doi: 10.1016/j.vaccine.2006.05.097. Epub 2006 Jun 12. Vaccine. 2006. PMID: 16860907
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
Bhatt A, Fujiwara N, Bhatt K, Gurcha SS, Kremer L, Chen B, Chan J, Porcelli SA, Kobayashi K, Besra GS, Jacobs WR Jr. Bhatt A, et al. Among authors: chen b. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5157-62. doi: 10.1073/pnas.0608654104. Epub 2007 Mar 12. Proc Natl Acad Sci U S A. 2007. PMID: 17360388 Free PMC article.
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