Guarente L - Search Results

1

Superoxide dismutase 1 knock-down induces senescence in human fibroblasts.

Blander G, de Oliveira RM, Conboy CM, Haigis M, Guarente L. Blander G, et al. Among authors: guarente l. J Biol Chem. 2003 Oct 3;278(40):38966-9. doi: 10.1074/jbc.M307146200. Epub 2003 Jul 18. J Biol Chem. 2003. PMID: 12871978 Free article.

2

SIRT1 shows no substrate specificity in vitro.

Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. Blander G, et al. Among authors: guarente l. J Biol Chem. 2005 Mar 18;280(11):9780-5. doi: 10.1074/jbc.M414080200. Epub 2005 Jan 6. J Biol Chem. 2005. PMID: 15640142 Free article.

3

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.

Haigis MC, Guarente LP. Haigis MC, et al. Genes Dev. 2006 Nov 1;20(21):2913-21. doi: 10.1101/gad.1467506. Genes Dev. 2006. PMID: 17079682 Free article. Review.

4

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. Haigis MC, et al. Among authors: guarente l. Cell. 2006 Sep 8;126(5):941-54. doi: 10.1016/j.cell.2006.06.057. Cell. 2006. PMID: 16959573 Free article.

5

SIRT1 promotes differentiation of normal human keratinocytes.

Blander G, Bhimavarapu A, Mammone T, Maes D, Elliston K, Reich C, Matsui MS, Guarente L, Loureiro JJ. Blander G, et al. Among authors: guarente l. J Invest Dermatol. 2009 Jan;129(1):41-9. doi: 10.1038/jid.2008.179. Epub 2008 Jun 19. J Invest Dermatol. 2009. PMID: 18563176 Free PMC article.

6

The Sir2 family of protein deacetylases.

Blander G, Guarente L. Blander G, et al. Among authors: guarente l. Annu Rev Biochem. 2004;73:417-35. doi: 10.1146/annurev.biochem.73.011303.073651. Annu Rev Biochem. 2004. PMID: 15189148 Review.

7

SIRT1 deacetylates and positively regulates the nuclear receptor LXR.

Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. Li X, et al. Among authors: guarente l. Mol Cell. 2007 Oct 12;28(1):91-106. doi: 10.1016/j.molcel.2007.07.032. Mol Cell. 2007. PMID: 17936707 Free article.

8

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Nakagawa T, Lomb DJ, Haigis MC, Guarente L. Nakagawa T, et al. Among authors: guarente l. Cell. 2009 May 1;137(3):560-70. doi: 10.1016/j.cell.2009.02.026. Cell. 2009. PMID: 19410549 Free PMC article.

9

Calorie restriction extends yeast life span by lowering the level of NADH.

Lin SJ, Ford E, Haigis M, Liszt G, Guarente L. Lin SJ, et al. Among authors: guarente l. Genes Dev. 2004 Jan 1;18(1):12-6. doi: 10.1101/gad.1164804. Genes Dev. 2004. PMID: 14724176 Free PMC article.

10

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. Firestein R, et al. PLoS One. 2008 Apr 16;3(4):e2020. doi: 10.1371/journal.pone.0002020. PLoS One. 2008. PMID: 18414679 Free PMC article.

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