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Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.
Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Cid JM, De Lucas AI, Fernández J, Martínez S, Nieto C, Pastor J, Bakker MH, Biesmans I, Heylen LI, Megens AA. Andrés JI, et al. Among authors: bakker mh. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2719-25. doi: 10.1016/s0960-894x(03)00525-0. Bioorg Med Chem Lett. 2003. PMID: 12873501
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.
Pastor J, Alcázar J, Alvarez RM, Andrés JI, Cid JM, De Lucas AI, Díaz A, Fernández J, Font LM, Iturrino L, Lafuente C, Martínez S, Bakker MH, Biesmans I, Heylen LI, Megens AA. Pastor J, et al. Among authors: bakker mh. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2917-22. doi: 10.1016/j.bmcl.2004.03.031. Bioorg Med Chem Lett. 2004. PMID: 15125959
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.
Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Bakker MH, Biesmans I, Cid JM, De Lucas AI, Fernández J, Font LM, Hens KA, Iturrino L, Lenaerts I, Martínez S, Megens AA, Pastor J, Vermote PC, Steckler T. Andrés JI, et al. Among authors: bakker mh. J Med Chem. 2005 Mar 24;48(6):2054-71. doi: 10.1021/jm049619s. J Med Chem. 2005. PMID: 15771448
Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.
Andrés JI, Alcázar J, Alonso JM, Alvarez RM, Bakker MH, Biesmans I, Cid JM, De Lucas AI, Drinkenburg W, Fernández J, Font LM, Iturrino L, Langlois X, Lenaerts I, Martínez S, Megens AA, Pastor J, Pullan S, Steckler T. Andrés JI, et al. Among authors: bakker mh. Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. doi: 10.1016/j.bmc.2007.03.053. Epub 2007 Mar 21. Bioorg Med Chem. 2007. PMID: 17407815
Nuclei and subnuclei gene expression profiling in mammalian brain.
Bonaventure P, Guo H, Tian B, Liu X, Bittner A, Roland B, Salunga R, Ma XJ, Kamme F, Meurers B, Bakker M, Jurzak M, Leysen JE, Erlander MG. Bonaventure P, et al. Brain Res. 2002 Jul 5;943(1):38-47. doi: 10.1016/s0006-8993(02)02504-0. Brain Res. 2002. PMID: 12088837
52 results