Nicklaus M - Search Results

1

Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity.

Li P, Zhang M, Peach ML, Zhang X, Liu H, Nicklaus M, Yang D, Roller PP. Li P, et al. Among authors: nicklaus m. Biochem Biophys Res Commun. 2003 Aug 8;307(4):1038-44. doi: 10.1016/s0006-291x(03)01291-9. Biochem Biophys Res Commun. 2003. PMID: 12878216

2

Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain.

Li P, Peach ML, Zhang M, Liu H, Yang D, Nicklaus M, Roller PP. Li P, et al. Among authors: nicklaus m. Bioorg Med Chem Lett. 2003 Mar 10;13(5):895-9. doi: 10.1016/s0960-894x(03)00015-5. Bioorg Med Chem Lett. 2003. PMID: 12617916

3

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Sigano DM, et al. Among authors: nicklaus mc. J Med Chem. 2003 Apr 24;46(9):1571-9. doi: 10.1021/jm020476o. J Med Chem. 2003. PMID: 12699375

4

Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.

Li P, Zhang M, Long YQ, Peach ML, Liu H, Yang D, Nicklaus M, Roller PP. Li P, et al. Among authors: nicklaus m. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2173-7. doi: 10.1016/s0960-894x(03)00385-8. Bioorg Med Chem Lett. 2003. PMID: 12798329

5

Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: nicklaus mc. J Med Chem. 2004 Sep 23;47(20):4858-64. doi: 10.1021/jm049723+. J Med Chem. 2004. PMID: 15369389

6

Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology.

Lung FD, Chang CW, Chong MC, Liou CC, Li P, Peach ML, Nicklaus MC, Lou BS, Roller PP. Lung FD, et al. Biopolymers. 2005;80(5):628-35. doi: 10.1002/bip.20209. Biopolymers. 2005. PMID: 15660381

7

Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.

Oishi S, Karki RG, Kang SU, Wang X, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: nicklaus mc. J Med Chem. 2005 Feb 10;48(3):764-72. doi: 10.1021/jm0492709. J Med Chem. 2005. PMID: 15689160

8

Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.

Shi ZD, Karki RG, Oishi S, Worthy KM, Bindu LK, Dharmawardana PG, Nicklaus MC, Bottaro DP, Fisher RJ, Burke TR Jr. Shi ZD, et al. Among authors: nicklaus mc. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1385-8. doi: 10.1016/j.bmcl.2005.01.017. Bioorg Med Chem Lett. 2005. PMID: 15713392

9

Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic.

Oishi S, Karki RG, Shi ZD, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Maderia M, Hartley J, Nicklaus MC, Barchi JJ Jr, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: nicklaus mc. Bioorg Med Chem. 2005 Apr 1;13(7):2431-8. doi: 10.1016/j.bmc.2005.01.052. Bioorg Med Chem. 2005. PMID: 15755645

10

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: nicklaus mc. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

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