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Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.
Rehmann H, Rueppel A, Bos JL, Wittinghofer A. Rehmann H, et al. J Biol Chem. 2003 Jun 27;278(26):23508-14. doi: 10.1074/jbc.M301680200. Epub 2003 Apr 21. J Biol Chem. 2003. PMID: 12707263 Free article.
Epac is inhibited by an intramolecular interaction between the cAMP-binding domain and the catalytic region in the absence of cAMP. cAMP binding is proposed to induce a conformational change, which allows a LID, an alpha-helix at the C-terminal end of the cAMP-binding site, to co …
Epac is inhibited by an intramolecular interaction between the cAMP-binding domain and the catalytic region in the absence of cAMP. cAMP bin …
AF6 negatively regulates Rap1-induced cell adhesion.
Zhang Z, Rehmann H, Price LS, Riedl J, Bos JL. Zhang Z, et al. Among authors: rehmann h. J Biol Chem. 2005 Sep 30;280(39):33200-5. doi: 10.1074/jbc.M505057200. Epub 2005 Jul 28. J Biol Chem. 2005. PMID: 16051602 Free article.
Structural dynamics in the activation of Epac.
Harper SM, Wienk H, Wechselberger RW, Bos JL, Boelens R, Rehmann H. Harper SM, et al. Among authors: rehmann h. J Biol Chem. 2008 Mar 7;283(10):6501-8. doi: 10.1074/jbc.M707849200. Epub 2007 Dec 31. J Biol Chem. 2008. PMID: 18167352 Free article.
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.
Vliem MJ, Ponsioen B, Schwede F, Pannekoek WJ, Riedl J, Kooistra MR, Jalink K, Genieser HG, Bos JL, Rehmann H. Vliem MJ, et al. Among authors: rehmann h. Chembiochem. 2008 Sep 1;9(13):2052-4. doi: 10.1002/cbic.200800216. Chembiochem. 2008. PMID: 18633951 No abstract available.
80 results