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cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension.
Christensen AE, Selheim F, de Rooij J, Dremier S, Schwede F, Dao KK, Martinez A, Maenhaut C, Bos JL, Genieser HG, Døskeland SO. Christensen AE, et al. Among authors: schwede f. J Biol Chem. 2003 Sep 12;278(37):35394-402. doi: 10.1074/jbc.M302179200. Epub 2003 Jun 20. J Biol Chem. 2003. PMID: 12819211 Free article.
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.
Vliem MJ, Ponsioen B, Schwede F, Pannekoek WJ, Riedl J, Kooistra MR, Jalink K, Genieser HG, Bos JL, Rehmann H. Vliem MJ, et al. Among authors: schwede f. Chembiochem. 2008 Sep 1;9(13):2052-4. doi: 10.1002/cbic.200800216. Chembiochem. 2008. PMID: 18633951 No abstract available.
Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure.
Stokman G, Qin Y, Genieser HG, Schwede F, de Heer E, Bos JL, Bajema IM, van de Water B, Price LS. Stokman G, et al. Among authors: schwede f. J Am Soc Nephrol. 2011 May;22(5):859-72. doi: 10.1681/ASN.2010040423. Epub 2011 Apr 14. J Am Soc Nephrol. 2011. PMID: 21493776 Free PMC article.
Structure-guided design of selective Epac1 and Epac2 agonists.
Schwede F, Bertinetti D, Langerijs CN, Hadders MA, Wienk H, Ellenbroek JH, de Koning EJ, Bos JL, Herberg FW, Genieser HG, Janssen RA, Rehmann H. Schwede F, et al. PLoS Biol. 2015 Jan 20;13(1):e1002038. doi: 10.1371/journal.pbio.1002038. eCollection 2015 Jan. PLoS Biol. 2015. PMID: 25603503 Free PMC article.
98 results