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Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
Gande R, Gibson KJ, Brown AK, Krumbach K, Dover LG, Sahm H, Shioyama S, Oikawa T, Besra GS, Eggeling L. Gande R, et al. Among authors: gibson kj. J Biol Chem. 2004 Oct 22;279(43):44847-57. doi: 10.1074/jbc.M408648200. Epub 2004 Aug 11. J Biol Chem. 2004. PMID: 15308633 Free article.
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target.
Bhakta S, Besra GS, Upton AM, Parish T, Sholto-Douglas-Vernon C, Gibson KJ, Knutton S, Gordon S, DaSilva RP, Anderton MC, Sim E. Bhakta S, et al. Among authors: gibson kj. J Exp Med. 2004 May 3;199(9):1191-9. doi: 10.1084/jem.20031956. Epub 2004 Apr 26. J Exp Med. 2004. PMID: 15117974 Free PMC article.
115 results