Govindarajan B - Search Results

1

Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth.

Govindarajan B, Mizesko MC, Miller MS, Onda H, Nunnelley M, Casper K, Brat D, Cohen C, Arbiser JL. Govindarajan B, et al. Clin Cancer Res. 2003 Aug 15;9(9):3469-75. Clin Cancer Res. 2003. PMID: 12960139

2

Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase.

Govindarajan B, Klafter R, Miller MS, Mansur C, Mizesko M, Bai X, LaMontagne K Jr, Arbiser JL. Govindarajan B, et al. Mol Med. 2002 Jan;8(1):1-8. Mol Med. 2002. PMID: 11984000 Free PMC article.

3

Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis.

Arbiser JL, Govindarajan B, Bai X, Onda H, Kazlauskas A, Lim SD, Amin MB, Claesson-Welsh L. Arbiser JL, et al. Among authors: govindarajan b. Am J Pathol. 2002 Sep;161(3):781-6. doi: 10.1016/s0002-9440(10)64237-x. Am J Pathol. 2002. PMID: 12213705 Free PMC article.

4

Mitogen-actived protein kinase activation is an early event in melanoma progression.

Cohen C, Zavala-Pompa A, Sequeira JH, Shoji M, Sexton DG, Cotsonis G, Cerimele F, Govindarajan B, Macaron N, Arbiser JL. Cohen C, et al. Among authors: govindarajan b. Clin Cancer Res. 2002 Dec;8(12):3728-33. Clin Cancer Res. 2002. PMID: 12473582

5

Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling.

Govindarajan B, Bai X, Cohen C, Zhong H, Kilroy S, Louis G, Moses M, Arbiser JL. Govindarajan B, et al. J Biol Chem. 2003 Mar 14;278(11):9790-5. doi: 10.1074/jbc.M212929200. Epub 2003 Jan 3. J Biol Chem. 2003. PMID: 12514183 Free article.

6

Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain.

Govindarajan B, Brat DJ, Csete M, Martin WD, Murad E, Litani K, Cohen C, Cerimele F, Nunnelley M, Lefkove B, Yamamoto T, Lee C, Arbiser JL. Govindarajan B, et al. J Biol Chem. 2005 Feb 18;280(7):5870-4. doi: 10.1074/jbc.M411768200. Epub 2004 Dec 2. J Biol Chem. 2005. PMID: 15576369 Free article.

7

Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo.

Bhandarkar SS, Bromberg J, Carrillo C, Selvakumar P, Sharma RK, Perry BN, Govindarajan B, Fried L, Sohn A, Reddy K, Arbiser JL. Bhandarkar SS, et al. Among authors: govindarajan b. Clin Cancer Res. 2008 Sep 15;14(18):5743-8. doi: 10.1158/1078-0432.CCR-08-0405. Clin Cancer Res. 2008. PMID: 18794083 Free PMC article.

8

Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.

Bai X, Cerimele F, Ushio-Fukai M, Waqas M, Campbell PM, Govindarajan B, Der CJ, Battle T, Frank DA, Ye K, Murad E, Dubiel W, Soff G, Arbiser JL. Bai X, et al. Among authors: govindarajan b. J Biol Chem. 2003 Sep 12;278(37):35501-7. doi: 10.1074/jbc.M302967200. Epub 2003 Jun 19. J Biol Chem. 2003. PMID: 12816951 Free article.

9

Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.

Govindarajan B, Shah A, Cohen C, Arnold RS, Schechner J, Chung J, Mercurio AM, Alani R, Ryu B, Fan CY, Cuezva JM, Martinez M, Arbiser JL. Govindarajan B, et al. J Biol Chem. 2005 Apr 8;280(14):13936-43. doi: 10.1074/jbc.M500411200. Epub 2005 Feb 4. J Biol Chem. 2005. PMID: 15695519 Free article.

10

Wilms tumor 1 expression present in most melanomas but nearly absent in nevi.

Perry BN, Cohen C, Govindarajan B, Cotsonis G, Arbiser JL. Perry BN, et al. Among authors: govindarajan b. Arch Dermatol. 2006 Aug;142(8):1031-4. doi: 10.1001/archderm.142.8.1031. Arch Dermatol. 2006. PMID: 16924053

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