Greasley SE - Search Results

1

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.

Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA. Wolan DW, et al. Among authors: greasley se. Biochemistry. 2003 Sep 23;42(37):10904-14. doi: 10.1021/bi030106h. Biochemistry. 2003. PMID: 12974624

2

A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.

Su Y, Yamashita MM, Greasley SE, Mullen CA, Shim JH, Jennings PA, Benkovic SJ, Wilson IA. Su Y, et al. Among authors: greasley se. J Mol Biol. 1998 Aug 21;281(3):485-99. doi: 10.1006/jmbi.1998.1931. J Mol Biol. 1998. PMID: 9698564

3

New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.

Greasley SE, Yamashita MM, Cai H, Benkovic SJ, Boger DL, Wilson IA. Greasley SE, et al. Biochemistry. 1999 Dec 21;38(51):16783-93. doi: 10.1021/bi991888a. Biochemistry. 1999. PMID: 10606510

4

Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli.

Reyes VM, Greasley SE, Stura EA, Beardsley GP, Wilson IA. Reyes VM, et al. Among authors: greasley se. Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):1051-4. doi: 10.1107/s0907444900007800. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10944351

5

Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.

Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA. Greasley SE, et al. Nat Struct Biol. 2001 May;8(5):402-6. doi: 10.1038/87555. Nat Struct Biol. 2001. PMID: 11323713

6

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.

Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA. Greasley SE, et al. Biochemistry. 2001 Nov 13;40(45):13538-47. doi: 10.1021/bi011482+. Biochemistry. 2001. PMID: 11695901

7

Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.

Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA. Zhang Y, et al. Among authors: greasley se. Biochemistry. 2002 Dec 3;41(48):14206-15. doi: 10.1021/bi020522m. Biochemistry. 2002. PMID: 12450384

8

Structural insights into the avian AICAR transformylase mechanism.

Wolan DW, Greasley SE, Beardsley GP, Wilson IA. Wolan DW, et al. Among authors: greasley se. Biochemistry. 2002 Dec 31;41(52):15505-13. doi: 10.1021/bi020505x. Biochemistry. 2002. PMID: 12501179

9

Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.

Wolan DW, Cheong CG, Greasley SE, Wilson IA. Wolan DW, et al. Among authors: greasley se. Biochemistry. 2004 Feb 10;43(5):1171-83. doi: 10.1021/bi030162i. Biochemistry. 2004. PMID: 14756553

10

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.

Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Cheong CG, et al. Among authors: greasley se. J Biol Chem. 2004 Apr 23;279(17):18034-45. doi: 10.1074/jbc.M313691200. Epub 2004 Feb 13. J Biol Chem. 2004. PMID: 14966129 Free article.

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