Desharnais J - Search Results

1

Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: desharnais j. Bioorg Med Chem. 2003 Oct 1;11(20):4487-501. doi: 10.1016/s0968-0896(03)00456-5. Bioorg Med Chem. 2003. PMID: 13129585

2

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.

Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: desharnais j. Bioorg Med Chem. 2002 Aug;10(8):2739-49. doi: 10.1016/s0968-0896(02)00102-5. Bioorg Med Chem. 2002. PMID: 12057663

3

Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.

Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA. Zhang Y, et al. Among authors: desharnais j. Biochemistry. 2002 Dec 3;41(48):14206-15. doi: 10.1021/bi020522m. Biochemistry. 2002. PMID: 12450384

4

Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.

Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA. Zhang Y, et al. Among authors: desharnais j. Biochemistry. 2003 May 27;42(20):6043-56. doi: 10.1021/bi034219c. Biochemistry. 2003. PMID: 12755606

5

10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.

Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: desharnais j. Bioorg Med Chem. 2003 Oct 1;11(20):4503-9. doi: 10.1016/s0968-0896(03)00457-7. Bioorg Med Chem. 2003. PMID: 13129586

6

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL. Desharnais J, et al. Bioorg Med Chem. 2003 Oct 1;11(20):4511-21. doi: 10.1016/s0968-0896(03)00458-9. Bioorg Med Chem. 2003. PMID: 13129587

7

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts.

Berg T, Cohen SB, Desharnais J, Sonderegger C, Maslyar DJ, Goldberg J, Boger DL, Vogt PK. Berg T, et al. Among authors: desharnais j. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3830-5. doi: 10.1073/pnas.062036999. Epub 2002 Mar 12. Proc Natl Acad Sci U S A. 2002. PMID: 11891322 Free PMC article.

8

Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions.

Boger DL, Desharnais J, Capps K. Boger DL, et al. Among authors: desharnais j. Angew Chem Int Ed Engl. 2003 Sep 15;42(35):4138-76. doi: 10.1002/anie.200300574. Angew Chem Int Ed Engl. 2003. PMID: 14502729 Review.

9

Erythropoietin mimetics derived from solution phase combinatorial libraries.

Goldberg J, Jin Q, Ambroise Y, Satoh S, Desharnais J, Capps K, Boger DL. Goldberg J, et al. Among authors: desharnais j. J Am Chem Soc. 2002 Jan 30;124(4):544-55. doi: 10.1021/ja0118789. J Am Chem Soc. 2002. PMID: 11804483

10

A facile route to paclitaxel C-10 carbamates.

Ballatore C, Aspland SE, Castillo R, Desharnais J, Eustaquio T, Sun C, Castellino AJ, Smith AB 3rd. Ballatore C, et al. Among authors: desharnais j. Bioorg Med Chem Lett. 2005 May 16;15(10):2477-80. doi: 10.1016/j.bmcl.2005.03.072. Bioorg Med Chem Lett. 2005. PMID: 15863300

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