Hedrick MP - Search Results

1

Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: hedrick mp. Bioorg Med Chem. 2003 Oct 1;11(20):4487-501. doi: 10.1016/s0968-0896(03)00456-5. Bioorg Med Chem. 2003. PMID: 13129585

2

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.

Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: hedrick mp. Bioorg Med Chem. 2002 Aug;10(8):2739-49. doi: 10.1016/s0968-0896(02)00102-5. Bioorg Med Chem. 2002. PMID: 12057663

3

Multidrug resistance reversal activity of key ningalin analogues.

Soenen DR, Hwang I, Hedrick MP, Boger DL. Soenen DR, et al. Among authors: hedrick mp. Bioorg Med Chem Lett. 2003 May 19;13(10):1777-81. doi: 10.1016/s0960-894x(03)00294-4. Bioorg Med Chem Lett. 2003. PMID: 12729663

4

Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.

Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA. Zhang Y, et al. Among authors: hedrick mp. Biochemistry. 2003 May 27;42(20):6043-56. doi: 10.1021/bi034219c. Biochemistry. 2003. PMID: 12755606

5

Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.

Parrish JP, Kastrinsky DB, Stauffer F, Hedrick MP, Hwang I, Boger DL. Parrish JP, et al. Among authors: hedrick mp. Bioorg Med Chem. 2003 Aug 15;11(17):3815-38. doi: 10.1016/s0968-0896(03)00194-9. Bioorg Med Chem. 2003. PMID: 12901927

6

10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.

Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: hedrick mp. Bioorg Med Chem. 2003 Oct 1;11(20):4503-9. doi: 10.1016/s0968-0896(03)00457-7. Bioorg Med Chem. 2003. PMID: 13129586

7

A new class of highly cytotoxic diketopiperazines.

Boger DL, Fink BE, Hedrick MP. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem Lett. 2000 May 15;10(10):1019-20. doi: 10.1016/s0960-894x(00)00152-9. Bioorg Med Chem Lett. 2000. PMID: 10843206

8

Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase.

Boger DL, Labroli MA, Marsilje TH, Jin Q, Hedrick MP, Baker SJ, Shim JH, Benkovic SJ. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem. 2000 May;8(5):1075-86. doi: 10.1016/s0968-0896(00)00051-1. Bioorg Med Chem. 2000. PMID: 10882019

9

Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1471-5. doi: 10.1016/s0960-894x(00)00271-7. Bioorg Med Chem Lett. 2000. PMID: 10888335

10

alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution.

Boger DL, Miyauchi H, Hedrick MP. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1517-20. doi: 10.1016/s0960-894x(01)00211-6. Bioorg Med Chem Lett. 2001. PMID: 11412972

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