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Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: tavassoli a. Bioorg Med Chem. 2003 Oct 1;11(20):4487-501. doi: 10.1016/s0968-0896(03)00456-5. Bioorg Med Chem. 2003. PMID: 13129585
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: tavassoli a. Bioorg Med Chem. 2002 Aug;10(8):2739-49. doi: 10.1016/s0968-0896(02)00102-5. Bioorg Med Chem. 2002. PMID: 12057663
Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Cheng H, et al. Among authors: tavassoli a. Bioorg Med Chem. 2005 May 16;13(10):3593-9. doi: 10.1016/j.bmc.2004.11.049. Bioorg Med Chem. 2005. PMID: 15848772
192 results