Hwang I - Search Results

1

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL. Desharnais J, et al. Among authors: hwang i. Bioorg Med Chem. 2003 Oct 1;11(20):4511-21. doi: 10.1016/s0968-0896(03)00458-9. Bioorg Med Chem. 2003. PMID: 13129587

2

Multidrug resistance reversal activity of key ningalin analogues.

Soenen DR, Hwang I, Hedrick MP, Boger DL. Soenen DR, et al. Among authors: hwang i. Bioorg Med Chem Lett. 2003 May 19;13(10):1777-81. doi: 10.1016/s0960-894x(03)00294-4. Bioorg Med Chem Lett. 2003. PMID: 12729663

3

Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.

McComas CC, Crowley BM, Hwang I, Boger DL. McComas CC, et al. Among authors: hwang i. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2933-6. doi: 10.1016/s0960-894x(03)00513-4. Bioorg Med Chem Lett. 2003. PMID: 14611861

4

Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives.

Parrish JP, Trzupek JD, Hughes TV, Hwang I, Boger DL. Parrish JP, et al. Among authors: hwang i. Bioorg Med Chem. 2004 Nov 15;12(22):5845-56. doi: 10.1016/j.bmc.2004.08.032. Bioorg Med Chem. 2004. PMID: 15498660

5

Multidrug resistance reversal activity of permethyl ningalin B amide derivatives.

Tao H, Hwang I, Boger DL. Tao H, et al. Among authors: hwang i. Bioorg Med Chem Lett. 2004 Dec 20;14(24):5979-81. doi: 10.1016/j.bmcl.2004.10.002. Bioorg Med Chem Lett. 2004. PMID: 15546712

6

Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.

Du W, Hardouin C, Cheng H, Hwang I, Boger DL. Du W, et al. Among authors: hwang i. Bioorg Med Chem Lett. 2005 Jan 3;15(1):103-6. doi: 10.1016/j.bmcl.2004.10.025. Bioorg Med Chem Lett. 2005. PMID: 15582420

7

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.

Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. Leung D, et al. Among authors: hwang i. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1423-8. doi: 10.1016/j.bmcl.2004.12.085. Bioorg Med Chem Lett. 2005. PMID: 15713400

8

Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

Cheng H, Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Cheng H, et al. Among authors: hwang i. Bioorg Med Chem. 2005 May 16;13(10):3577-85. doi: 10.1016/j.bmc.2004.12.004. Bioorg Med Chem. 2005. PMID: 15848770

9

Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.

Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Chong Y, et al. Among authors: hwang i. Bioorg Med Chem. 2005 May 16;13(10):3587-92. doi: 10.1016/j.bmc.2004.11.050. Bioorg Med Chem. 2005. PMID: 15848771

10

Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.

Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Cheng H, et al. Among authors: hwang i. Bioorg Med Chem. 2005 May 16;13(10):3593-9. doi: 10.1016/j.bmc.2004.11.049. Bioorg Med Chem. 2005. PMID: 15848772

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