Rosowsky A - Search Results

1

Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.

Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH. Rosowsky A, et al. Cancer Res. 1992 Apr 15;52(8):2148-55. Cancer Res. 1992. PMID: 1313737

2

Analogues of methotrexate and aminopterin with gamma-methylene and gamma-cyano substitution of the glutamate side chain: synthesis and in vitro biological activity.

Rosowsky A, Bader H, Freisheim JH. Rosowsky A, et al. J Med Chem. 1991 Jan;34(1):203-8. doi: 10.1021/jm00105a031. J Med Chem. 1991. PMID: 1992118

3

Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate.

Rosowsky A, Forsch RA, Moran RG, Freisheim JH. Rosowsky A, et al. J Med Chem. 1991 Jan;34(1):227-34. doi: 10.1021/jm00105a036. J Med Chem. 1991. PMID: 1992122

4

Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain.

Rosowsky A, Bader H, Freisheim JH. Rosowsky A, et al. J Med Chem. 1991 Feb;34(2):574-9. doi: 10.1021/jm00106a016. J Med Chem. 1991. PMID: 1995880

5

Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.

Rosowsky A, Forsch RA, Bader H, Freisheim JH. Rosowsky A, et al. J Med Chem. 1991 Apr;34(4):1447-54. doi: 10.1021/jm00108a032. J Med Chem. 1991. PMID: 2016722

6

Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.

Rosowsky A, Bader H, Kohler W, Freisheim JH, Moran RG. Rosowsky A, et al. J Med Chem. 1988 Jul;31(7):1338-44. doi: 10.1021/jm00402a014. J Med Chem. 1988. PMID: 2898531

7

Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.

Rosowsky A, Bader H, Forsch RA, Moran RG, Freisheim JH. Rosowsky A, et al. J Med Chem. 1988 Apr;31(4):763-8. doi: 10.1021/jm00399a013. J Med Chem. 1988. PMID: 3351853

8

Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.

Rosowsky A, Bader H, Cucchi CA, Moran RG, Kohler W, Freisheim JH. Rosowsky A, et al. J Med Chem. 1988 Jul;31(7):1332-7. doi: 10.1021/jm00402a013. J Med Chem. 1988. PMID: 3385730

9

Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.

Rosowsky A, Moran RG, Freisheim JH, Bader H, Forsch RA, Solan VC. Rosowsky A, et al. NCI Monogr. 1987;(5):145-52. NCI Monogr. 1987. PMID: 3431589

10

Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.

Rosowsky A, Forsch RA, Reich VE, Freisheim JH, Moran RG. Rosowsky A, et al. J Med Chem. 1992 May 1;35(9):1578-88. doi: 10.1021/jm00087a012. J Med Chem. 1992. PMID: 1578484

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