Denis D - Search Results

1

Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.

Lau CK, Bélanger PC, Dufresne C, Scheigetz J, Therien M, Fitzsimmons B, Young RN, Ford-Hutchinson AW, Riendeau D, Denis D, et al. Lau CK, et al. Among authors: denis d. J Med Chem. 1992 Apr 3;35(7):1299-318. doi: 10.1021/jm00085a019. J Med Chem. 1992. PMID: 1313879

2

Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors.

Denis D, Falgueyret JP, Riendeau D, Abramovitz M. Denis D, et al. J Biol Chem. 1991 Mar 15;266(8):5072-9. J Biol Chem. 1991. PMID: 1848236 Free article.

3

Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.

Lau CK, Bélanger PC, Scheigetz J, Dufresne C, Williams HW, Maycock AL, Guindon Y, Bach T, Dallob AL, Denis D, et al. Lau CK, et al. Among authors: denis d. J Med Chem. 1989 Jun;32(6):1190-7. doi: 10.1021/jm00126a008. J Med Chem. 1989. PMID: 2542553

4

Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.

Hutchinson JH, Riendeau D, Brideau C, Chan C, Delorme D, Denis D, Falgueyret JP, Fortin R, Guay J, Hamel P, et al. Hutchinson JH, et al. Among authors: denis d. J Med Chem. 1993 Sep 17;36(19):2771-87. doi: 10.1021/jm00071a008. J Med Chem. 1993. PMID: 8410991

5

Identification of an indole series of prostaglandin D2 receptor antagonists.

Sturino CF, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Brideau C, Cauchon E, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, O'Neill G, Wang Z, Zamboni R, Metters KM, Young RN. Sturino CF, et al. Among authors: denis d. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3043-8. doi: 10.1016/j.bmcl.2006.02.062. Epub 2006 Mar 10. Bioorg Med Chem Lett. 2006. PMID: 16529930

6

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

Sturino CF, O'Neill G, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Aubin Y, Bateman KP, Chauret N, Day SH, Lévesque JF, Seto C, Silva JH, Trimble LA, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, Abraham WM, Jones T, McAuliffe M, Piechuta H, Nicoll-Griffith DA, Wang Z, Zamboni R, Young RN, Metters KM. Sturino CF, et al. Among authors: denis d. J Med Chem. 2007 Feb 22;50(4):794-806. doi: 10.1021/jm0603668. J Med Chem. 2007. PMID: 17300164

7

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

Beaulieu C, Guay D, Wang Z, Leblanc Y, Roy P, Dufresne C, Zamboni R, Berthelette C, Day S, Tsou N, Denis D, Greig G, Mathieu MC, O'Neill G. Beaulieu C, et al. Among authors: denis d. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2696-700. doi: 10.1016/j.bmcl.2008.03.015. Epub 2008 Mar 10. Bioorg Med Chem Lett. 2008. PMID: 18359630

8

Discovery of potent and selective DP1 receptor antagonists in the azaindole series.

Leblanc Y, Roy P, Dufresne C, Lachance N, Wang Z, O'Neill G, Greig G, Denis D, Mathieu MC, Slipetz D, Sawyer N, Tsou N. Leblanc Y, et al. Among authors: denis d. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2125-8. doi: 10.1016/j.bmcl.2009.03.010. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19307115

9

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.

Brideau C, Chan C, Charleson S, Denis D, Evans JF, Ford-Hutchinson AW, Fortin R, Gillard JW, Guay J, Guévremont D, et al. Brideau C, et al. Among authors: denis d. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807. doi: 10.1139/y92-107. Can J Physiol Pharmacol. 1992. PMID: 1330258

10

Stimulation of 5-lipoxygenase activity under conditions which promote lipid peroxidation.

Riendeau D, Denis D, Choo LY, Nathaniel DJ. Riendeau D, et al. Among authors: denis d. Biochem J. 1989 Oct 15;263(2):565-72. doi: 10.1042/bj2630565. Biochem J. 1989. PMID: 2512907 Free PMC article.

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