Rose J - Search Results

1

Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.

Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR. Scarborough RM, et al. Among authors: rose j. J Biol Chem. 1992 Jul 5;267(19):13146-9. J Biol Chem. 1992. PMID: 1320011 Free article.

2

Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms.

Scarborough RM, Rose JW, Naughton MA, Phillips DR, Nannizzi L, Arfsten A, Campbell AM, Charo IF. Scarborough RM, et al. Among authors: rose jw. J Biol Chem. 1993 Jan 15;268(2):1058-65. J Biol Chem. 1993. PMID: 8419314 Free article.

3

Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa.

Scarborough RM, Naughton MA, Teng W, Rose JW, Phillips DR, Nannizzi L, Arfsten A, Campbell AM, Charo IF. Scarborough RM, et al. Among authors: rose jw. J Biol Chem. 1993 Jan 15;268(2):1066-73. J Biol Chem. 1993. PMID: 8419315 Free article.

4

Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri.

Scarborough RM, Rose JW, Hsu MA, Phillips DR, Fried VA, Campbell AM, Nannizzi L, Charo IF. Scarborough RM, et al. Among authors: rose jw. J Biol Chem. 1991 May 25;266(15):9359-62. J Biol Chem. 1991. PMID: 2033037 Free article.

5

Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.

Su T, Naughton MA, Smyth MS, Rose JW, Arfsten AE, McCowan JR, Jakubowski JA, Wyss VL, Ruterbories KJ, Sall DJ, Scarborough RM. Su T, et al. Among authors: rose jw. J Med Chem. 1997 Dec 19;40(26):4308-18. doi: 10.1021/jm9704863. J Med Chem. 1997. PMID: 9435900

6

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes.

Smyth MS, Rose J, Mehrotra MM, Heath J, Ruhter G, Schotten T, Seroogy J, Volkots D, Pandey A, Scarborough RM. Smyth MS, et al. Among authors: rose j. Bioorg Med Chem Lett. 2001 May 21;11(10):1289-92. doi: 10.1016/s0960-894x(01)00215-3. Bioorg Med Chem Lett. 2001. PMID: 11392539

7

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro[5.5]undecanes.

Pandey A, Seroogy J, Volkots D, Smyth MS, Rose J, Mehrotra MM, Heath J, Ruhter G, Schotten T, Scarborough RM. Pandey A, et al. Among authors: rose j. Bioorg Med Chem Lett. 2001 May 21;11(10):1293-6. doi: 10.1016/s0960-894x(01)00216-5. Bioorg Med Chem Lett. 2001. PMID: 11392540

8

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes.

Mehrotra MM, Heath JA, Rose JW, Smyth MS, Seroogy J, Volkots DL, Ruhter G, Schotten T, Alaimo L, Park G, Pandey A, Scarborough RM. Mehrotra MM, et al. Among authors: rose jw. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1103-7. doi: 10.1016/s0960-894x(02)00095-1. Bioorg Med Chem Lett. 2002. PMID: 11909727

9

Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.

Pandey A, Volkots DL, Seroogy JM, Rose JW, Yu JC, Lambing JL, Hutchaleelaha A, Hollenbach SJ, Abe K, Giese NA, Scarborough RM. Pandey A, et al. Among authors: rose jw. J Med Chem. 2002 Aug 15;45(17):3772-93. doi: 10.1021/jm020143r. J Med Chem. 2002. PMID: 12166950

10

Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists.

Mehrotra MM, Heath JA, Smyth MS, Pandey A, Rose JW, Seroogy JM, Volkots DL, Nannizzi-Alaimo L, Park GL, Lambing JL, Hollenbach SJ, Scarborough RM. Mehrotra MM, et al. Among authors: rose jw. J Med Chem. 2004 Apr 8;47(8):2037-61. doi: 10.1021/jm030354b. J Med Chem. 2004. PMID: 15056002

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